Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis

Michael K. Racke, Barbara Cannella, Paul Albert, Michael Sporn, Cedric S. Raine, Dale E. Mcfarlin

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Experimental allergic encephalomyelitls (EAE) Is an autoimmune disease characterized by inflammation and demyellnation in the central nervous system (CNS). Administration of transforming growth factor-β?(TGF-β) has been shown to inhibit EAE. In this study, the possible role of endogenous TGF-β in the regulation of relapsing EAE produced by the transfer of myelin basic protein-specific T cell lines was assessed. Although TGF-β is not present In the normal CNS, this cytokine was detected by immunohistology In areas of central nervous system inflammation in both acute and chronic disease. The administration of anti-TGF-β at the disease onset led to a worsening of the clinical course of EAE and more extensive pathological lesions. These findings provide direct evidence for a role of endogenous TGF-β In the remissions seen in chronic relapsing EAE.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalInternational Immunology
Volume4
Issue number5
DOIs
StatePublished - May 1 1992

Keywords

  • Experimental allergic encephalomyelitius
  • Transforming growth factor β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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