Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis

Michael K. Racke, Barbara Cannella, Paul Albert, Michael Sporn, Cedric S. Raine, Dale E. Mcfarlin

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Experimental allergic encephalomyelitls (EAE) Is an autoimmune disease characterized by inflammation and demyellnation in the central nervous system (CNS). Administration of transforming growth factor-β?(TGF-β) has been shown to inhibit EAE. In this study, the possible role of endogenous TGF-β in the regulation of relapsing EAE produced by the transfer of myelin basic protein-specific T cell lines was assessed. Although TGF-β is not present In the normal CNS, this cytokine was detected by immunohistology In areas of central nervous system inflammation in both acute and chronic disease. The administration of anti-TGF-β at the disease onset led to a worsening of the clinical course of EAE and more extensive pathological lesions. These findings provide direct evidence for a role of endogenous TGF-β In the remissions seen in chronic relapsing EAE.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalInternational Immunology
Volume4
Issue number5
DOIs
StatePublished - May 1 1992

Keywords

  • Experimental allergic encephalomyelitius
  • Transforming growth factor β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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