Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis

Michael K. Racke, Barbara Cannella, Paul Albert, Michael Sporn, Cedric S. Raine, Dale E. Mcfarlin

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Experimental allergic encephalomyelitls (EAE) Is an autoimmune disease characterized by inflammation and demyellnation in the central nervous system (CNS). Administration of transforming growth factor-β?(TGF-β) has been shown to inhibit EAE. In this study, the possible role of endogenous TGF-β in the regulation of relapsing EAE produced by the transfer of myelin basic protein-specific T cell lines was assessed. Although TGF-β is not present In the normal CNS, this cytokine was detected by immunohistology In areas of central nervous system inflammation in both acute and chronic disease. The administration of anti-TGF-β at the disease onset led to a worsening of the clinical course of EAE and more extensive pathological lesions. These findings provide direct evidence for a role of endogenous TGF-β In the remissions seen in chronic relapsing EAE.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
JournalInternational Immunology
Volume4
Issue number5
DOIs
StatePublished - May 1992

Fingerprint

Autoimmune Experimental Encephalomyelitis
Growth Factors
Neurology
Transforming Growth Factors
Central Nervous System
Inflammation
Myelin Basic Protein
T-cells
Acute Disease
Autoimmune Diseases
Chronic Disease
Cytokines
Proteins
T-Lymphocytes
Cell Line
Acute
Evidence
Intercellular Signaling Peptides and Proteins
Growth factors
Protein

Keywords

  • Experimental allergic encephalomyelitius
  • Transforming growth factor β

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Neuropsychology and Physiological Psychology
  • Transplantation
  • Immunology

Cite this

Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis. / Racke, Michael K.; Cannella, Barbara; Albert, Paul; Sporn, Michael; Raine, Cedric S.; Mcfarlin, Dale E.

In: International Immunology, Vol. 4, No. 5, 05.1992, p. 615-620.

Research output: Contribution to journalArticle

Racke, Michael K. ; Cannella, Barbara ; Albert, Paul ; Sporn, Michael ; Raine, Cedric S. ; Mcfarlin, Dale E. / Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis. In: International Immunology. 1992 ; Vol. 4, No. 5. pp. 615-620.
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