Abstract
Experimental allergic encephalomyelitls (EAE) Is an autoimmune disease characterized by inflammation and demyellnation in the central nervous system (CNS). Administration of transforming growth factor-β?(TGF-β) has been shown to inhibit EAE. In this study, the possible role of endogenous TGF-β in the regulation of relapsing EAE produced by the transfer of myelin basic protein-specific T cell lines was assessed. Although TGF-β is not present In the normal CNS, this cytokine was detected by immunohistology In areas of central nervous system inflammation in both acute and chronic disease. The administration of anti-TGF-β at the disease onset led to a worsening of the clinical course of EAE and more extensive pathological lesions. These findings provide direct evidence for a role of endogenous TGF-β In the remissions seen in chronic relapsing EAE.
Original language | English (US) |
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Pages (from-to) | 615-620 |
Number of pages | 6 |
Journal | International Immunology |
Volume | 4 |
Issue number | 5 |
DOIs | |
State | Published - May 1992 |
Keywords
- Experimental allergic encephalomyelitius
- Transforming growth factor β
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology