Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

Jie Ma, Jian Sun, Huan Zhang, Rui Zhang, Wan Hu Kang, Cheng Ge Gao, Hai Sheng Liu, Xue Hong Ma, Zi Xin Min, Wen Xiang Zhao, Qi Lan Ning, Shu Hong Wang, Yin Cang Zhang, Ting Wei Guo, She Min Lu

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalNeuroscience Letters
Volume462
Issue number2
DOIs
Publication statusPublished - Sep 22 2009

    Fingerprint

Keywords

  • Association
  • DAOA
  • Haplotype
  • SNP
  • Schizophrenia
  • TDT

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ma, J., Sun, J., Zhang, H., Zhang, R., Kang, W. H., Gao, C. G., ... Lu, S. M. (2009). Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample. Neuroscience Letters, 462(2), 105-108. https://doi.org/10.1016/j.neulet.2009.06.070