Everolimus-eluting bioresorbable vascular scaffolds for treatment of complex chronic total occlusions

Jiang Ming Fam, Soledad Ojeda, Roberto Garbo, Azeem Latib, Alessio La Manna, Beatriz Vaquerizo, Marouane Boukhris, Georgios J. Vlachojannis, Robert Jan Van Geuns, Babu Ezhumalai, Hiroyoshi Kawamoto, Jors Van Der Sijde, Cordula Felix, Manuel Pan, Roberta Serdoz, Giacomo Giovanni Boccuzzi, Marcella De Paolis, Gennaro Sardella, Massimo Mancone, Corrado TamburinoPieter C. Smits, Carlo Di Mario, Ashok Seth, Antonio Serra, Antonio Colombo, Patrick Serruys, Alfredo R. Galassi, Felix Zijlstra, Nicolas M. Van Mieghem, Roberto Diletti, Holger Thiele

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Aims: Bioresorbable vascular scaffolds (BVS) represent a novel therapeutic option for the treatment of coronary artery diseases. The objective of this study was to evaluate the feasibility of BVS implantation in complex chronic total occlusions (CTO). Methods and results: The present report is a multicentre registry evaluating results after BVS deployment in challenging CTO lesions, defined as J-CTO score ≥2 (difficult or very difficult). A total of 105 patients were included in the present analysis. The mean J-CTO score was 2.61 (difficult 52.4%, very difficult 47.6%). Device success and procedural success rates were 98.1% and 97.1%, respectively. The retrograde approach was used in 25.7% of cases. After wire crossing, predilatation was performed in all cases with a mean predilatation balloon diameter of 2.73±0.43 mm. The mean scaffold length was 59.75±25.85 mm, with post-dilatation performed in 89.5% of the cases and a mean post-dilatation balloon diameter of 3.35±0.44 mm. Post-PCI minimal lumen diameter was 2.50±0.51 mm and percentage diameter stenosis 14.53±10.31%. At six-month follow-up, a total of three events were reported: one periprocedural myocardial infarction, one late scaffold thrombosis and one additional target lesion revascularisation. Conclusions: The present report suggests the feasibility of BVS implantation in complex CTO lesions, given adequate lesion preparation and post-dilatation, with good acute angiographic results and midterm clinical outcomes.

Original languageEnglish (US)
Pages (from-to)355-363
Number of pages9
JournalEuroIntervention
Volume13
Issue number3
DOIs
StatePublished - Jun 2017
Externally publishedYes

Keywords

  • Bioresorbable scaffolds
  • Chronic coronary total occlusion
  • Stable angina

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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