Event-related potentials in an emotional go/no-go task and remission of geriatric depression

George S. Alexopoulos, Christopher F. Murphy, Faith M. Gunning-Dixon, Balkrishna Kalayam, Richard Katz, Dora Kanellopoulos, Glenda R. Etwaroo, Sibel Klimstra, John J. Foxe

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalNeuroReport
Volume18
Issue number3
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

Gyrus Cinguli
Evoked Potentials
Geriatrics
Antidepressive Agents
Citalopram
Therapeutics

Keywords

  • Depression
  • Electroencephalogram
  • Error-related negativity
  • Event-related potential
  • Geriatric
  • Treatment response

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alexopoulos, G. S., Murphy, C. F., Gunning-Dixon, F. M., Kalayam, B., Katz, R., Kanellopoulos, D., ... Foxe, J. J. (2007). Event-related potentials in an emotional go/no-go task and remission of geriatric depression. NeuroReport, 18(3), 217-221. https://doi.org/10.1097/WNR.0b013e328013ceda

Event-related potentials in an emotional go/no-go task and remission of geriatric depression. / Alexopoulos, George S.; Murphy, Christopher F.; Gunning-Dixon, Faith M.; Kalayam, Balkrishna; Katz, Richard; Kanellopoulos, Dora; Etwaroo, Glenda R.; Klimstra, Sibel; Foxe, John J.

In: NeuroReport, Vol. 18, No. 3, 02.2007, p. 217-221.

Research output: Contribution to journalArticle

Alexopoulos, GS, Murphy, CF, Gunning-Dixon, FM, Kalayam, B, Katz, R, Kanellopoulos, D, Etwaroo, GR, Klimstra, S & Foxe, JJ 2007, 'Event-related potentials in an emotional go/no-go task and remission of geriatric depression', NeuroReport, vol. 18, no. 3, pp. 217-221. https://doi.org/10.1097/WNR.0b013e328013ceda
Alexopoulos GS, Murphy CF, Gunning-Dixon FM, Kalayam B, Katz R, Kanellopoulos D et al. Event-related potentials in an emotional go/no-go task and remission of geriatric depression. NeuroReport. 2007 Feb;18(3):217-221. https://doi.org/10.1097/WNR.0b013e328013ceda
Alexopoulos, George S. ; Murphy, Christopher F. ; Gunning-Dixon, Faith M. ; Kalayam, Balkrishna ; Katz, Richard ; Kanellopoulos, Dora ; Etwaroo, Glenda R. ; Klimstra, Sibel ; Foxe, John J. / Event-related potentials in an emotional go/no-go task and remission of geriatric depression. In: NeuroReport. 2007 ; Vol. 18, No. 3. pp. 217-221.
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