Event-related potential and clinical correlates of neurodysfunction in obsessive-compulsive disorder

James Towey; Gerard Bruder; Craig Tenke; Paul Leite; Concetta DeCaria; David Friedman; Eric Hollander

doi:10.1016/0165-1781(93)90103-N

Event-related potential and clinical correlates of neurodysfunction in obsessive-compulsive disorder

James Towey, Gerard Bruder, Craig Tenke, Paul Leite, Concetta DeCaria, David Friedman, Eric Hollander

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The current study confirmed with increased sample sizes our preliminary findings of event-related potential (ERP) abnormalities in obsessive-compulsive disorder (OCD) (Towey et al., 1990) and examined their relationship to symptom severity, treatment response, and neurological soft signs. Unmedicated patients (n - 17) showed larger negativities in N200 and slow wave regions than normal control subjects (n - 16) to correctly detected auditory "oddball" stimuli. N200 amplitude was larger over left than right hemispheres of OCD patients, but not normal control subjects. Greater N200 amplitude correlated with less severe obsessions, better response to subsequent treatment with serotonin reuptake blockers, and fewer neurological soft signs in OCD. With increased task difficulty, N200 and P300 latencies lengthened for normal subjects, but not for OCD patients. The abnormal ERP pattern in OCD supports hypotheses of cortical hyperarousal and overfocused attention.

Original language	English (US)
Pages (from-to)	167-181
Number of pages	15
Journal	Psychiatry Research
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(93)90103-N
State	Published - Nov 1993
Externally published	Yes

Keywords

Electrophysiology
anxiety disorder
cortical arousal
neurological soft signs

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(93)90103-N

Cite this

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title = "Event-related potential and clinical correlates of neurodysfunction in obsessive-compulsive disorder",

abstract = "The current study confirmed with increased sample sizes our preliminary findings of event-related potential (ERP) abnormalities in obsessive-compulsive disorder (OCD) (Towey et al., 1990) and examined their relationship to symptom severity, treatment response, and neurological soft signs. Unmedicated patients (n - 17) showed larger negativities in N200 and slow wave regions than normal control subjects (n - 16) to correctly detected auditory {"}oddball{"} stimuli. N200 amplitude was larger over left than right hemispheres of OCD patients, but not normal control subjects. Greater N200 amplitude correlated with less severe obsessions, better response to subsequent treatment with serotonin reuptake blockers, and fewer neurological soft signs in OCD. With increased task difficulty, N200 and P300 latencies lengthened for normal subjects, but not for OCD patients. The abnormal ERP pattern in OCD supports hypotheses of cortical hyperarousal and overfocused attention.",

keywords = "Electrophysiology, anxiety disorder, cortical arousal, neurological soft signs",

author = "James Towey and Gerard Bruder and Craig Tenke and Paul Leite and Concetta DeCaria and David Friedman and Eric Hollander",

note = "Funding Information: Acknowledgments. The research reported was supported in part by a grant to Dr. Towey from the National Institute of Mental Health (MH-44815) and RSDA awards to Dr. Hollander (MH-00750) and Dr. Friedman (MH-00510). A Faculty Development Award to Dr. Towey from Mercy College also provided some support.",

year = "1993",

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doi = "10.1016/0165-1781(93)90103-N",

language = "English (US)",

volume = "49",

pages = "167--181",

journal = "Psychiatry Research",

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AU - Tenke, Craig

AU - Leite, Paul

AU - DeCaria, Concetta

AU - Friedman, David

AU - Hollander, Eric

N1 - Funding Information: Acknowledgments. The research reported was supported in part by a grant to Dr. Towey from the National Institute of Mental Health (MH-44815) and RSDA awards to Dr. Hollander (MH-00750) and Dr. Friedman (MH-00510). A Faculty Development Award to Dr. Towey from Mercy College also provided some support.

PY - 1993/11

Y1 - 1993/11

N2 - The current study confirmed with increased sample sizes our preliminary findings of event-related potential (ERP) abnormalities in obsessive-compulsive disorder (OCD) (Towey et al., 1990) and examined their relationship to symptom severity, treatment response, and neurological soft signs. Unmedicated patients (n - 17) showed larger negativities in N200 and slow wave regions than normal control subjects (n - 16) to correctly detected auditory "oddball" stimuli. N200 amplitude was larger over left than right hemispheres of OCD patients, but not normal control subjects. Greater N200 amplitude correlated with less severe obsessions, better response to subsequent treatment with serotonin reuptake blockers, and fewer neurological soft signs in OCD. With increased task difficulty, N200 and P300 latencies lengthened for normal subjects, but not for OCD patients. The abnormal ERP pattern in OCD supports hypotheses of cortical hyperarousal and overfocused attention.

AB - The current study confirmed with increased sample sizes our preliminary findings of event-related potential (ERP) abnormalities in obsessive-compulsive disorder (OCD) (Towey et al., 1990) and examined their relationship to symptom severity, treatment response, and neurological soft signs. Unmedicated patients (n - 17) showed larger negativities in N200 and slow wave regions than normal control subjects (n - 16) to correctly detected auditory "oddball" stimuli. N200 amplitude was larger over left than right hemispheres of OCD patients, but not normal control subjects. Greater N200 amplitude correlated with less severe obsessions, better response to subsequent treatment with serotonin reuptake blockers, and fewer neurological soft signs in OCD. With increased task difficulty, N200 and P300 latencies lengthened for normal subjects, but not for OCD patients. The abnormal ERP pattern in OCD supports hypotheses of cortical hyperarousal and overfocused attention.

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Event-related potential and clinical correlates of neurodysfunction in obsessive-compulsive disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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