Evasion and subversion of antigen presentation by Mycobacterium tuberculosis: REVIEW ARTICLE

A. Baena, S. A. Porcelli

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

Mycobacterium tuberculosis is one of the most successful of human pathogens and has acquired the ability to establish latent or progressive infection and persist even in the presence of a fully functioning immune system. The ability of M. tuberculosis to avoid immune-mediated clearance is likely to reflect a highly evolved and coordinated program of immune evasion strategies, including some that interfere with antigen presentation to prevent or alter the quality of T-cell responses. Here, we review an extensive array of published studies supporting the view that antigen presentation pathways are targeted at many points by pathogenic mycobacteria. These studies show the multiple potential mechanisms by which M. tuberculosis may actively inhibit, subvert or otherwise modulate antigen presentation by major histocompatibility complex class I, class II and CD1 molecules. Unraveling the mechanisms by which M. tuberculosis evades or modulates antigen presentation is of critical importance for the development of more effective new vaccines based on live attenuated mycobacterial strains.

Original languageEnglish (US)
Pages (from-to)189-204
Number of pages16
JournalTissue Antigens
Volume74
Issue number3
DOIs
StatePublished - Sep 2009

Keywords

  • Antigen presentation
  • CD1
  • Immune evasion
  • Major histocompatibility complex class I
  • Major histocompatibility complex class II
  • Mycobacterium tuberculosis
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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