Evaluation of two techniques of partial urethral obstruction in the male rat model of bladder outlet obstruction

Arnold Melman, Moses T. Tar, Judd Boczko, George Christ, Albert C. Leung, Weixin Zhao, Robert G. Russell

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objectives. To perform a comparison to determine which of two methods of partial urethral ligation produces the most consistent outcome and fewest side effects. Such a study has not been previously reported. Partial urethral ligation is a means of causing reproducible bladder outlet obstruction. In the male rat model, partial urethral obstruction can be performed either by perineal incision and bulbous urethral ligation or retropubic incision and midprostatic obstruction. Methods. Fifteen male Sprague-Dawley rats were studied. Five were selected for bulbous urethral obstruction through a perineal incision, five for midprostatic obstruction using a retropubic approach, and five for a sham operation through a perineal incision. Results. The operative time was shorter and morbidity lower with the perineal approach compared with the retropubic approach. Inflammation or infection, or both, were seen in the prostate, bladder, proximal urethra, ureters, and kidneys in the rats in which a midprostatic obstruction was performed. The proximal urethra and prostate were mildly inflamed in those rats that underwent bulbous obstruction. Sham-operated rats exhibited mild prostatitis only. Conclusions. The perineal approach to the bulbous urethra is the method of choice for creating a partial urethral obstruction model of bladder outlet obstruction in the male rat.

Original languageEnglish (US)
Pages (from-to)1127-1133
Number of pages7
JournalUrology
Volume66
Issue number5
DOIs
StatePublished - Nov 2005
Externally publishedYes

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Urethral Obstruction
Urinary Bladder Neck Obstruction
Urethra
Ligation
Prostate
Prostatitis
Ureter
Operative Time
Sprague Dawley Rats
Urinary Bladder
Inflammation
Morbidity
Kidney
Infection

ASJC Scopus subject areas

  • Urology

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Evaluation of two techniques of partial urethral obstruction in the male rat model of bladder outlet obstruction. / Melman, Arnold; Tar, Moses T.; Boczko, Judd; Christ, George; Leung, Albert C.; Zhao, Weixin; Russell, Robert G.

In: Urology, Vol. 66, No. 5, 11.2005, p. 1127-1133.

Research output: Contribution to journalArticle

Melman, Arnold ; Tar, Moses T. ; Boczko, Judd ; Christ, George ; Leung, Albert C. ; Zhao, Weixin ; Russell, Robert G. / Evaluation of two techniques of partial urethral obstruction in the male rat model of bladder outlet obstruction. In: Urology. 2005 ; Vol. 66, No. 5. pp. 1127-1133.
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