Evaluation of third trimester uterine artery flow velocity indices in relationship to perinatal complications

G. Ghosh, A. Breborowicz, M. Bra̧zert, M. Maczkiewicz, M. Kobelski, M. Dubiel, Saemundur Gudmundsson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective. Uterine artery Doppler is becoming a routine part of pregnancy surveillance in high-risk pregnancies. Which blood flow velocity waveform index to measure is debated and the 'notch' in early diastole is not widely accepted, as it is a subjective measure. The aim of the present study was to evaluate the different indices in the prediction of adverse outcome of pregnancies suspected for intrauterine fetal growth restriction (IUGR). Methods. Uterine artery blood flow was recorded in 217 pregnancies admitted for Doppler ultrasound surveillance due to suspected IUGR. The median gestational age at examination was 38 weeks (range 25-42 weeks). Only cases having bilateral uterine artery notching were included in the evaluation. The uterine artery Doppler spectrum was analyzed for different indices, including evaluation of notch and end-diastolic velocities. Umbilical artery Doppler velocimetry was also performed. The outcome variables chosen were: a small-for-gestational-age (SGA) newborn, preterm birth, and abdominal delivery. ROC-curve calculations were used to compare the different indices. Results. The uterine artery blood velocity pulsatility index (PI) and resistance indices (RI) were the best predictors of adverse outcome of pregnancy. Apart from premature birth, the systolic/end-diastolic ratio was less predictive of adverse outcome. The indices including only diastolic blood velocities were the least predictive of adverse outcome. The group with notch velocity above end-diastolic velocity was compared with those having notch velocity below the end-diastolic velocity. No difference in outcome was seen between the two groups. Conclusions. RI and PI as measures of third trimester utero-placental vascular impedance are the best predictors of adverse outcome of IUGR-suspected pregnancies.

Original languageEnglish (US)
Pages (from-to)551-555
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume19
Issue number9
DOIs
StatePublished - Sep 1 2006
Externally publishedYes

Fingerprint

Uterine Artery
Third Pregnancy Trimester
Fetal Development
Premature Birth
Pregnancy Outcome
Pregnancy
Gestational Age
High-Risk Pregnancy
Doppler Ultrasonography
Umbilical Arteries
Diastole
Blood Flow Velocity
Rheology
Electric Impedance
ROC Curve
Cesarean Section
Blood Vessels

Keywords

  • Doppler
  • Growth restriction
  • Notch
  • Pregnancy
  • Uterine artery
  • Vascular impedance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Ghosh, G., Breborowicz, A., Bra̧zert, M., Maczkiewicz, M., Kobelski, M., Dubiel, M., & Gudmundsson, S. (2006). Evaluation of third trimester uterine artery flow velocity indices in relationship to perinatal complications. Journal of Maternal-Fetal and Neonatal Medicine, 19(9), 551-555. https://doi.org/10.1080/14767050600852510

Evaluation of third trimester uterine artery flow velocity indices in relationship to perinatal complications. / Ghosh, G.; Breborowicz, A.; Bra̧zert, M.; Maczkiewicz, M.; Kobelski, M.; Dubiel, M.; Gudmundsson, Saemundur.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 19, No. 9, 01.09.2006, p. 551-555.

Research output: Contribution to journalArticle

Ghosh, G, Breborowicz, A, Bra̧zert, M, Maczkiewicz, M, Kobelski, M, Dubiel, M & Gudmundsson, S 2006, 'Evaluation of third trimester uterine artery flow velocity indices in relationship to perinatal complications', Journal of Maternal-Fetal and Neonatal Medicine, vol. 19, no. 9, pp. 551-555. https://doi.org/10.1080/14767050600852510
Ghosh, G. ; Breborowicz, A. ; Bra̧zert, M. ; Maczkiewicz, M. ; Kobelski, M. ; Dubiel, M. ; Gudmundsson, Saemundur. / Evaluation of third trimester uterine artery flow velocity indices in relationship to perinatal complications. In: Journal of Maternal-Fetal and Neonatal Medicine. 2006 ; Vol. 19, No. 9. pp. 551-555.
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