Abstract
Objective: To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. Design: Prospective and controlled. Setting: Primate Research Center. Participants: Six reproductive age cycling female baboons (Papio cyanocephalus anubis). Interventions: The animals were divided into two groups. Group A received a total of 19 pulses of 0.83 μg/kg leuprolide acetate (LA) on a 12-hour dosing schedule. Group B received Nal-Lys (3 mg/kg then 1 mg/kg every other day) for 1 week and then added an identical 19 pulses of LA while continuing Nal-Lys therapy. Main Outcome Measures: Characterization of the gonadotropin response was done by col lecting serum samples at 15, 0, 15, 30, 60, 90, 120, 240, and 480 minutes relative to the injection of the LA. Results: After equivalent baseline responses, the baboons pretreated with Nal-Lys had an increased LH and FSH response to the administration of the LA. After a total of 19 pulses of the LA, the Nal-Lys-treated animals had an increased FSH response in comparison to the untreated controls. This indicates that the extent of gonadotrope desensitization was reduced in the presence of the GnRH antagonist. Conclusions: The presence of GnRH antagonist reduces the extent of gonadotrope desensitization in response to the administration of repetitive pulses of GnRH agonist.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 848-854 |
| Number of pages | 7 |
| Journal | Fertility and Sterility |
| Volume | 64 |
| Issue number | 4 |
| State | Published - 1995 |
| Externally published | Yes |
Fingerprint
Keywords
- baboons
- GnRH analogues
- Gonadorelin
- gonadotropes
- gonadotropins
- primates
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Evaluation of the impact of concurrent gonadotropin-releasing hormone (GnRH) antagonist administration on GnRH agonist-induced gonadotrope desensitization. / Illions, E. H.; Scott, R. T.; Carey, K. D.; Navot, D.
In: Fertility and Sterility, Vol. 64, No. 4, 1995, p. 848-854.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of the impact of concurrent gonadotropin-releasing hormone (GnRH) antagonist administration on GnRH agonist-induced gonadotrope desensitization
AU - Illions, E. H.
AU - Scott, R. T.
AU - Carey, K. D.
AU - Navot, D.
PY - 1995
Y1 - 1995
N2 - Objective: To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. Design: Prospective and controlled. Setting: Primate Research Center. Participants: Six reproductive age cycling female baboons (Papio cyanocephalus anubis). Interventions: The animals were divided into two groups. Group A received a total of 19 pulses of 0.83 μg/kg leuprolide acetate (LA) on a 12-hour dosing schedule. Group B received Nal-Lys (3 mg/kg then 1 mg/kg every other day) for 1 week and then added an identical 19 pulses of LA while continuing Nal-Lys therapy. Main Outcome Measures: Characterization of the gonadotropin response was done by col lecting serum samples at 15, 0, 15, 30, 60, 90, 120, 240, and 480 minutes relative to the injection of the LA. Results: After equivalent baseline responses, the baboons pretreated with Nal-Lys had an increased LH and FSH response to the administration of the LA. After a total of 19 pulses of the LA, the Nal-Lys-treated animals had an increased FSH response in comparison to the untreated controls. This indicates that the extent of gonadotrope desensitization was reduced in the presence of the GnRH antagonist. Conclusions: The presence of GnRH antagonist reduces the extent of gonadotrope desensitization in response to the administration of repetitive pulses of GnRH agonist.
AB - Objective: To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. Design: Prospective and controlled. Setting: Primate Research Center. Participants: Six reproductive age cycling female baboons (Papio cyanocephalus anubis). Interventions: The animals were divided into two groups. Group A received a total of 19 pulses of 0.83 μg/kg leuprolide acetate (LA) on a 12-hour dosing schedule. Group B received Nal-Lys (3 mg/kg then 1 mg/kg every other day) for 1 week and then added an identical 19 pulses of LA while continuing Nal-Lys therapy. Main Outcome Measures: Characterization of the gonadotropin response was done by col lecting serum samples at 15, 0, 15, 30, 60, 90, 120, 240, and 480 minutes relative to the injection of the LA. Results: After equivalent baseline responses, the baboons pretreated with Nal-Lys had an increased LH and FSH response to the administration of the LA. After a total of 19 pulses of the LA, the Nal-Lys-treated animals had an increased FSH response in comparison to the untreated controls. This indicates that the extent of gonadotrope desensitization was reduced in the presence of the GnRH antagonist. Conclusions: The presence of GnRH antagonist reduces the extent of gonadotrope desensitization in response to the administration of repetitive pulses of GnRH agonist.
KW - baboons
KW - GnRH analogues
KW - Gonadorelin
KW - gonadotropes
KW - gonadotropins
KW - primates
UR - http://www.scopus.com/inward/record.url?scp=0029119103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029119103&partnerID=8YFLogxK
M3 - Article
C2 - 7672160
AN - SCOPUS:0029119103
VL - 64
SP - 848
EP - 854
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 4
ER -