Evaluation of the impact of concurrent gonadotropin-releasing hormone (GnRH) antagonist administration on GnRH agonist-induced gonadotrope desensitization

E. H. Illions, R. T. Scott, K. D. Carey, D. Navot

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. Design: Prospective and controlled. Setting: Primate Research Center. Participants: Six reproductive age cycling female baboons (Papio cyanocephalus anubis). Interventions: The animals were divided into two groups. Group A received a total of 19 pulses of 0.83 μg/kg leuprolide acetate (LA) on a 12-hour dosing schedule. Group B received Nal-Lys (3 mg/kg then 1 mg/kg every other day) for 1 week and then added an identical 19 pulses of LA while continuing Nal-Lys therapy. Main Outcome Measures: Characterization of the gonadotropin response was done by col lecting serum samples at 15, 0, 15, 30, 60, 90, 120, 240, and 480 minutes relative to the injection of the LA. Results: After equivalent baseline responses, the baboons pretreated with Nal-Lys had an increased LH and FSH response to the administration of the LA. After a total of 19 pulses of the LA, the Nal-Lys-treated animals had an increased FSH response in comparison to the untreated controls. This indicates that the extent of gonadotrope desensitization was reduced in the presence of the GnRH antagonist. Conclusions: The presence of GnRH antagonist reduces the extent of gonadotrope desensitization in response to the administration of repetitive pulses of GnRH agonist.

Original languageEnglish (US)
Pages (from-to)848-854
Number of pages7
JournalFertility and Sterility
Volume64
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Leuprolide
Hormone Antagonists
Gonadotropin-Releasing Hormone
Papio
Papio anubis
Gonadotropins
Primates
Appointments and Schedules
Outcome Assessment (Health Care)
Injections
Therapeutics
Serum
Research

Keywords

  • baboons
  • GnRH analogues
  • Gonadorelin
  • gonadotropes
  • gonadotropins
  • primates

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Evaluation of the impact of concurrent gonadotropin-releasing hormone (GnRH) antagonist administration on GnRH agonist-induced gonadotrope desensitization. / Illions, E. H.; Scott, R. T.; Carey, K. D.; Navot, D.

In: Fertility and Sterility, Vol. 64, No. 4, 1995, p. 848-854.

Research output: Contribution to journalArticle

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