Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid

Daiane Francine Meinerz, Jéssie H. Sudati, Danúbia B. Dos Santos, Andressa Frediani, Eduardo E. Alberto, Josiane Allebrandt, Jeferson L. Franco, Nilda B V Barbosa, Michael Aschner, João Batista T Da Rocha

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

(S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalArchives of Toxicology
Volume85
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Aspartic Acid
Antioxidants
Glutathione Peroxidase
Derivatives
Toxicology
Acids
Sulfhydryl Compounds
Toxicity
Rats
Brain
Oxidoreductases
Pharmacology
dimethyl 2-(3-(phenyltellanyl)propanamido)succinate
In Vitro Techniques
Experiments

Keywords

  • Antioxidant
  • Genotoxicity
  • Mutagenicity
  • Organotellurium derivative

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Meinerz, D. F., Sudati, J. H., Dos Santos, D. B., Frediani, A., Alberto, E. E., Allebrandt, J., ... Da Rocha, J. B. T. (2011). Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. Archives of Toxicology, 85(1), 43-49. https://doi.org/10.1007/s00204-010-0555-3

Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. / Meinerz, Daiane Francine; Sudati, Jéssie H.; Dos Santos, Danúbia B.; Frediani, Andressa; Alberto, Eduardo E.; Allebrandt, Josiane; Franco, Jeferson L.; Barbosa, Nilda B V; Aschner, Michael; Da Rocha, João Batista T.

In: Archives of Toxicology, Vol. 85, No. 1, 2011, p. 43-49.

Research output: Contribution to journalArticle

Meinerz, DF, Sudati, JH, Dos Santos, DB, Frediani, A, Alberto, EE, Allebrandt, J, Franco, JL, Barbosa, NBV, Aschner, M & Da Rocha, JBT 2011, 'Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid', Archives of Toxicology, vol. 85, no. 1, pp. 43-49. https://doi.org/10.1007/s00204-010-0555-3
Meinerz, Daiane Francine ; Sudati, Jéssie H. ; Dos Santos, Danúbia B. ; Frediani, Andressa ; Alberto, Eduardo E. ; Allebrandt, Josiane ; Franco, Jeferson L. ; Barbosa, Nilda B V ; Aschner, Michael ; Da Rocha, João Batista T. / Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. In: Archives of Toxicology. 2011 ; Vol. 85, No. 1. pp. 43-49.
@article{28ac31d00f6d470f90d737af82b1315b,
title = "Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid",
abstract = "(S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.",
keywords = "Antioxidant, Genotoxicity, Mutagenicity, Organotellurium derivative",
author = "Meinerz, {Daiane Francine} and Sudati, {J{\'e}ssie H.} and {Dos Santos}, {Dan{\'u}bia B.} and Andressa Frediani and Alberto, {Eduardo E.} and Josiane Allebrandt and Franco, {Jeferson L.} and Barbosa, {Nilda B V} and Michael Aschner and {Da Rocha}, {Jo{\~a}o Batista T}",
year = "2011",
doi = "10.1007/s00204-010-0555-3",
language = "English (US)",
volume = "85",
pages = "43--49",
journal = "Archiv fur Toxikologie",
issn = "0003-9446",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid

AU - Meinerz, Daiane Francine

AU - Sudati, Jéssie H.

AU - Dos Santos, Danúbia B.

AU - Frediani, Andressa

AU - Alberto, Eduardo E.

AU - Allebrandt, Josiane

AU - Franco, Jeferson L.

AU - Barbosa, Nilda B V

AU - Aschner, Michael

AU - Da Rocha, João Batista T

PY - 2011

Y1 - 2011

N2 - (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.

AB - (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.

KW - Antioxidant

KW - Genotoxicity

KW - Mutagenicity

KW - Organotellurium derivative

UR - http://www.scopus.com/inward/record.url?scp=84983725936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983725936&partnerID=8YFLogxK

U2 - 10.1007/s00204-010-0555-3

DO - 10.1007/s00204-010-0555-3

M3 - Article

AN - SCOPUS:84983725936

VL - 85

SP - 43

EP - 49

JO - Archiv fur Toxikologie

JF - Archiv fur Toxikologie

SN - 0003-9446

IS - 1

ER -