Abstract
(S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 43-49 |
| Number of pages | 7 |
| Journal | Archives of Toxicology |
| Volume | 85 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2011 |
| Externally published | Yes |
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Keywords
- Antioxidant
- Genotoxicity
- Mutagenicity
- Organotellurium derivative
ASJC Scopus subject areas
- Medicine(all)
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. / Meinerz, Daiane Francine; Sudati, Jéssie H.; Dos Santos, Danúbia B.; Frediani, Andressa; Alberto, Eduardo E.; Allebrandt, Josiane; Franco, Jeferson L.; Barbosa, Nilda B V; Aschner, Michael; Da Rocha, João Batista T.
In: Archives of Toxicology, Vol. 85, No. 1, 2011, p. 43-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid
AU - Meinerz, Daiane Francine
AU - Sudati, Jéssie H.
AU - Dos Santos, Danúbia B.
AU - Frediani, Andressa
AU - Alberto, Eduardo E.
AU - Allebrandt, Josiane
AU - Franco, Jeferson L.
AU - Barbosa, Nilda B V
AU - Aschner, Michael
AU - Da Rocha, João Batista T
PY - 2011
Y1 - 2011
N2 - (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.
AB - (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.
KW - Antioxidant
KW - Genotoxicity
KW - Mutagenicity
KW - Organotellurium derivative
UR - http://www.scopus.com/inward/record.url?scp=84983725936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983725936&partnerID=8YFLogxK
U2 - 10.1007/s00204-010-0555-3
DO - 10.1007/s00204-010-0555-3
M3 - Article
AN - SCOPUS:84983725936
VL - 85
SP - 43
EP - 49
JO - Archiv fur Toxikologie
JF - Archiv fur Toxikologie
SN - 0003-9446
IS - 1
ER -