Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid

Daiane Francine Meinerz, Jéssie H. Sudati, Danúbia B. Dos Santos, Andressa Frediani, Eduardo E. Alberto, Josiane Allebrandt, Jeferson L. Franco, Nilda B V Barbosa, Michael Aschner, João Batista T Da Rocha

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8 Scopus citations

Abstract

(S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalArchives of Toxicology
Volume85
Issue number1
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Keywords

  • Antioxidant
  • Genotoxicity
  • Mutagenicity
  • Organotellurium derivative

ASJC Scopus subject areas

  • Medicine(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Meinerz, D. F., Sudati, J. H., Dos Santos, D. B., Frediani, A., Alberto, E. E., Allebrandt, J., ... Da Rocha, J. B. T. (2011). Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. Archives of Toxicology, 85(1), 43-49. https://doi.org/10.1007/s00204-010-0555-3