Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid

Daiane Francine Meinerz; Jéssie H. Sudati; Danúbia B. Dos Santos; Andressa Frediani; Eduardo E. Alberto; Josiane Allebrandt; Jeferson L. Franco; Nilda B.V. Barbosa; Michael Aschner; João Batista T. Da Rocha

doi:10.1007/s00204-010-0555-3

Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid

Daiane Francine Meinerz, Jéssie H. Sudati, Danúbia B. Dos Santos, Andressa Frediani, Eduardo E. Alberto, Josiane Allebrandt, Jeferson L. Franco, Nilda B.V. Barbosa, Michael Aschner, João Batista T. Da Rocha

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

(S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.

Original language	English (US)
Pages (from-to)	43-49
Number of pages	7
Journal	Archives of Toxicology
Volume	85
Issue number	1
DOIs	https://doi.org/10.1007/s00204-010-0555-3
State	Published - Jan 2011

Keywords

Antioxidant
Genotoxicity
Mutagenicity
Organotellurium derivative

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

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Meinerz, D. F., Sudati, J. H., Dos Santos, D. B., Frediani, A., Alberto, E. E., Allebrandt, J., Franco, J. L., Barbosa, N. B. V., Aschner, M., & Da Rocha, J. B. T. (2011). Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. Archives of Toxicology, 85(1), 43-49. https://doi.org/10.1007/s00204-010-0555-3

Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. / Meinerz, Daiane Francine; Sudati, Jéssie H.; Dos Santos, Danúbia B.; Frediani, Andressa; Alberto, Eduardo E.; Allebrandt, Josiane; Franco, Jeferson L.; Barbosa, Nilda B.V.; Aschner, Michael; Da Rocha, João Batista T.

In: Archives of Toxicology, Vol. 85, No. 1, 01.2011, p. 43-49.

Research output: Contribution to journal › Article › peer-review

Meinerz, DF, Sudati, JH, Dos Santos, DB, Frediani, A, Alberto, EE, Allebrandt, J, Franco, JL, Barbosa, NBV, Aschner, M & Da Rocha, JBT 2011, 'Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid', Archives of Toxicology, vol. 85, no. 1, pp. 43-49. https://doi.org/10.1007/s00204-010-0555-3

Meinerz, Daiane Francine ; Sudati, Jéssie H. ; Dos Santos, Danúbia B. ; Frediani, Andressa ; Alberto, Eduardo E. ; Allebrandt, Josiane ; Franco, Jeferson L. ; Barbosa, Nilda B.V. ; Aschner, Michael ; Da Rocha, João Batista T. / Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid. In: Archives of Toxicology. 2011 ; Vol. 85, No. 1. pp. 43-49.

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abstract = "(S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.",

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