TY - JOUR
T1 - Evaluation of the biological effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative of aspartic acid
AU - Meinerz, Daiane Francine
AU - Sudati, Jéssie H.
AU - Dos Santos, Danúbia B.
AU - Frediani, Andressa
AU - Alberto, Eduardo E.
AU - Allebrandt, Josiane
AU - Franco, Jeferson L.
AU - Barbosa, Nilda B.V.
AU - Aschner, Michael
AU - Da Rocha, João Batista T.
N1 - Funding Information:
Acknowledgments We are thankful for the Wnancial support from CNPq, UFSM, FAPERGS, and CAPES.
PY - 2011/1
Y1 - 2011/1
N2 - (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.
AB - (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate, a new telluroamino acid derivative, showed remarkable glutathione peroxidase (GPx)-like activity, attesting to its antioxidant potential. However, the stability and toxicity of this compound has not yet been investigated. The present study was designed to investigate the pharmacological/toxicological properties of this compound in vitro and in vivo. In vitro, this telluroamino acid derivative significantly blocked spontaneous and Fe(II)-induced TBARS formation in rat brain homogenates, demonstrating high antioxidant activity. In addition, it exhibited GPx-like and thiol oxidase activities. However, when subcutaneously administered to mice, (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate indicated genotoxic and mutagenic effect in adult male mice. Considering the differential effects of (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate in vitro and in vivo, additional experiments are needed to elucidate the mechanism(s) by which this compound displays its antioxidant/toxicological effects.
KW - Antioxidant
KW - Genotoxicity
KW - Mutagenicity
KW - Organotellurium derivative
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U2 - 10.1007/s00204-010-0555-3
DO - 10.1007/s00204-010-0555-3
M3 - Article
AN - SCOPUS:84983725936
SN - 0340-5761
VL - 85
SP - 43
EP - 49
JO - Archives of Toxicology
JF - Archives of Toxicology
IS - 1
ER -