Evaluation of the acute cardiac and central nervous system effects of the fluorocarbon trifluoromethane in baboons

Craig A. Branch, D. A. Goldberg, J. R. Ewing, S. C. Fagan, S. S. Butt, J. Gayner

Research output: Contribution to journalArticle

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Abstract

The gaseous fluorocarbon trifluoromethane has recently been investigated for its potential as an in vivo gaseous indicator for nuclear magnetic resonance studies of brain perfusion. Trifluoromethane may also have significant value as a replacement for chlorofluorocarbon fire retardants. Because of possible species-specific cardiotoxic and anesthetic properties, the toxicological evaluation of trifluoromethane in primates (Papio anubis) is necessary prior to its evaluation in humans. We report the acute cardiac and central nervous system effects of trifluoromethane in eight anesthetized baboons. A dose-response effect was established for respiratory rate, electroencephalogram, and cardiac sinus rate, which exhibited a stepwise decrease from 10% trifluoromethane. No spontaneous arrhythmias were noted, and arterial blood pressure remained unchanged at any inspired level. Intravenous epinephrine infusions (1 μg/kg) induced transient cardiac arrhythmia in 1 animal only at 70% FC-23 (v/v) trifluoromethane. Trifluoromethane appears to induce mild dose-related physiological changes at inspired levels of 30% or more, indicative of an anesthetic effect. These data suggest that trifluoromethane may be safe to use in humans, without significant adverse acute effects, at an inspired level of 30%.

Original languageEnglish (US)
Pages (from-to)25-35
Number of pages11
JournalJournal of Toxicology and Environmental Health
Volume43
Issue number1
StatePublished - 1994
Externally publishedYes

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Fluorocarbons
Anesthetics
Papio
Neurology
Central Nervous System
Chlorofluorocarbons
Blood pressure
Flame retardants
Electroencephalography
Brain
Animals
Nuclear magnetic resonance
Cardiac Arrhythmias
Papio anubis
Flame Retardants
fluoroform
Respiratory Rate
Intravenous Infusions
Toxicology
Primates

ASJC Scopus subject areas

  • Toxicology
  • Pollution

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Evaluation of the acute cardiac and central nervous system effects of the fluorocarbon trifluoromethane in baboons. / Branch, Craig A.; Goldberg, D. A.; Ewing, J. R.; Fagan, S. C.; Butt, S. S.; Gayner, J.

In: Journal of Toxicology and Environmental Health, Vol. 43, No. 1, 1994, p. 25-35.

Research output: Contribution to journalArticle

Branch, Craig A. ; Goldberg, D. A. ; Ewing, J. R. ; Fagan, S. C. ; Butt, S. S. ; Gayner, J. / Evaluation of the acute cardiac and central nervous system effects of the fluorocarbon trifluoromethane in baboons. In: Journal of Toxicology and Environmental Health. 1994 ; Vol. 43, No. 1. pp. 25-35.
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