Evaluation of the ability of d-penicillamine to protect rats against the neurotoxicity induced by zinc pyridinethione, acrylamide, 2,5-hexanedione and p-bromophenylacetylurea

R. M. LoPachin, M. S. Weiler, K. D. Williams, R. E. Peterson

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4 Scopus citations


Dietary exposure of rats to three different concentrations of zinc pyridinethione (ZPT; 166, 332, 498 ppm) caused delayed onset failure in a treadmill test and, at the higher concentrations (332 and 498 ppm), death. Daily treatment with d-penicillamine (d-PEN) increased the latency period for treadmill failure and lethality. Comparable levels of toxicity were achieved only after d-PEN treated rats had consumed 2-3 times more ZPT than rats not treated with d-PEN. In contrast to ZPT, administration of d-PEN did not affect the onset of treadmill failure associated with acrylamide, p-bromophenylacetylurea or 2,5-hexanedione. Thus, d-PEN provided protection which was selective for ZPT.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
Issue number2
Publication statusPublished - Jan 1 1984
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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