Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls

Vivian L. Chin, Ziyong Cai, Leslie S. Lam, Bina Shah, Ping Zhou

Research output: Contribution to journalArticle

Abstract

Background: Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test. Objective: To determine the best predictive model for detecting puberty in girls. Subjects: Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n=20) or premature thelarche/premature adrenarche (n=15). Methods: Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram. Gonadotropins and E2 were analyzed using immunochemiluminometric assay. Logistic regression for CPP was performed. Results: The best predictor of CPP is the E2-change model based on 3- to 24-h values, providing 80% sensitivity and 87% specificity. Three-hour luteinizing hormone (LH) provided 75% sensitivity and 87% specificity. Basal LH lowered sensitivity to 65% and specificity to 53%. Conclusions: The E2-change model provided the best predictive power; however, 3-h LH was more practical and convenient when evaluating puberty in girls.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume28
Issue number3-4
DOIs
StatePublished - Mar 1 2015

Fingerprint

Puberty
Luteinizing Hormone
Gonadotropins
Adrenarche
Pelvic Bones
Sensitivity and Specificity
Gonadotropin-Releasing Hormone
Logistic Models
Hormones
Pharmacology
Central Precocious Puberty

Keywords

  • central precocious puberty
  • girls
  • GnRHa stimulation testing
  • leuprolide stimulation test

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls. / Chin, Vivian L.; Cai, Ziyong; Lam, Leslie S.; Shah, Bina; Zhou, Ping.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 28, No. 3-4, 01.03.2015, p. 387-392.

Research output: Contribution to journalArticle

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