Evaluation of possible effects of continued drug use on HIV progression among women

Anne M. Rompalo, Nina Shah, Joseph B. Margolick, Homayoon Farzadegan, Julia H. Arnsten, Paula Schuman, Josiah D. Rich, Lytt I. Gardner, Dawn K. Smith, David Vlahov

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Data from a prospective, multi-centred study of HIV infection in women (HIV Epidemiology Research Study [HERS]) was analysed to investigate the effect of continued injection drug use behaviours on progression to AIDS. All women enrolled in the HERS had at enrolment and at six-month intervals, a face-to-face interview which included specific injection drug use, a physical exam, and specimen collection that included T-cell subset analysis and HIV plasma RNA detection. Six hundred and thirty-nine HIV-infected women contributed 3021 person years of observation during 7.25 years of follow-up, and 299 of these women progressed to AIDS (46.8%). In multivariable analysis, there was no significantly increased risk of progression to AIDS for women reporting pre-baseline injection drug use [hazard ratio (HR) = 1.07 (0.78, 1.47)] or reported injection drug use during follow-up [HR = 0.89 (0.66, 1.21)] compared with never injecting. In a separate multivariable-model, comparing women who reported no injection in past six months to active injection drug users, the frequency of injection during the previous six months measured by daily injection [HR = 0.97 (0.61, 1.55)] or less than daily injection [HR = 0.84 (0.54, 1.33)] was not associated with progression to AIDS. Being in drug treatment was independently associated with a slower progression to AIDS [HR = 0.41 (0.28, 0.59)]. Neither injection drug use, nor frequency of injection drug use was associated with progression to AIDS among HIV infected women. Initiation of antiretroviral therapy among drug users should be based on readiness for treatment rather than concern about faster progression.

Original languageEnglish (US)
Pages (from-to)322-327
Number of pages6
JournalInternational Journal of STD and AIDS
Volume15
Issue number5
DOIs
StatePublished - May 2004

Fingerprint

HIV
Injections
Pharmaceutical Preparations
Acquired Immunodeficiency Syndrome
Drug Users
Epidemiology
Specimen Handling
T-Lymphocyte Subsets
Research
HIV Infections
Therapeutics
Observation
RNA
Interviews

Keywords

  • Drug use
  • HIV progression
  • Women

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Immunology

Cite this

Evaluation of possible effects of continued drug use on HIV progression among women. / Rompalo, Anne M.; Shah, Nina; Margolick, Joseph B.; Farzadegan, Homayoon; Arnsten, Julia H.; Schuman, Paula; Rich, Josiah D.; Gardner, Lytt I.; Smith, Dawn K.; Vlahov, David.

In: International Journal of STD and AIDS, Vol. 15, No. 5, 05.2004, p. 322-327.

Research output: Contribution to journalArticle

Rompalo, AM, Shah, N, Margolick, JB, Farzadegan, H, Arnsten, JH, Schuman, P, Rich, JD, Gardner, LI, Smith, DK & Vlahov, D 2004, 'Evaluation of possible effects of continued drug use on HIV progression among women', International Journal of STD and AIDS, vol. 15, no. 5, pp. 322-327. https://doi.org/10.1258/095646204323012814
Rompalo, Anne M. ; Shah, Nina ; Margolick, Joseph B. ; Farzadegan, Homayoon ; Arnsten, Julia H. ; Schuman, Paula ; Rich, Josiah D. ; Gardner, Lytt I. ; Smith, Dawn K. ; Vlahov, David. / Evaluation of possible effects of continued drug use on HIV progression among women. In: International Journal of STD and AIDS. 2004 ; Vol. 15, No. 5. pp. 322-327.
@article{8e3f9a090e4747ed9a8fbec92cfe81c5,
title = "Evaluation of possible effects of continued drug use on HIV progression among women",
abstract = "Data from a prospective, multi-centred study of HIV infection in women (HIV Epidemiology Research Study [HERS]) was analysed to investigate the effect of continued injection drug use behaviours on progression to AIDS. All women enrolled in the HERS had at enrolment and at six-month intervals, a face-to-face interview which included specific injection drug use, a physical exam, and specimen collection that included T-cell subset analysis and HIV plasma RNA detection. Six hundred and thirty-nine HIV-infected women contributed 3021 person years of observation during 7.25 years of follow-up, and 299 of these women progressed to AIDS (46.8{\%}). In multivariable analysis, there was no significantly increased risk of progression to AIDS for women reporting pre-baseline injection drug use [hazard ratio (HR) = 1.07 (0.78, 1.47)] or reported injection drug use during follow-up [HR = 0.89 (0.66, 1.21)] compared with never injecting. In a separate multivariable-model, comparing women who reported no injection in past six months to active injection drug users, the frequency of injection during the previous six months measured by daily injection [HR = 0.97 (0.61, 1.55)] or less than daily injection [HR = 0.84 (0.54, 1.33)] was not associated with progression to AIDS. Being in drug treatment was independently associated with a slower progression to AIDS [HR = 0.41 (0.28, 0.59)]. Neither injection drug use, nor frequency of injection drug use was associated with progression to AIDS among HIV infected women. Initiation of antiretroviral therapy among drug users should be based on readiness for treatment rather than concern about faster progression.",
keywords = "Drug use, HIV progression, Women",
author = "Rompalo, {Anne M.} and Nina Shah and Margolick, {Joseph B.} and Homayoon Farzadegan and Arnsten, {Julia H.} and Paula Schuman and Rich, {Josiah D.} and Gardner, {Lytt I.} and Smith, {Dawn K.} and David Vlahov",
year = "2004",
month = "5",
doi = "10.1258/095646204323012814",
language = "English (US)",
volume = "15",
pages = "322--327",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - Evaluation of possible effects of continued drug use on HIV progression among women

AU - Rompalo, Anne M.

AU - Shah, Nina

AU - Margolick, Joseph B.

AU - Farzadegan, Homayoon

AU - Arnsten, Julia H.

AU - Schuman, Paula

AU - Rich, Josiah D.

AU - Gardner, Lytt I.

AU - Smith, Dawn K.

AU - Vlahov, David

PY - 2004/5

Y1 - 2004/5

N2 - Data from a prospective, multi-centred study of HIV infection in women (HIV Epidemiology Research Study [HERS]) was analysed to investigate the effect of continued injection drug use behaviours on progression to AIDS. All women enrolled in the HERS had at enrolment and at six-month intervals, a face-to-face interview which included specific injection drug use, a physical exam, and specimen collection that included T-cell subset analysis and HIV plasma RNA detection. Six hundred and thirty-nine HIV-infected women contributed 3021 person years of observation during 7.25 years of follow-up, and 299 of these women progressed to AIDS (46.8%). In multivariable analysis, there was no significantly increased risk of progression to AIDS for women reporting pre-baseline injection drug use [hazard ratio (HR) = 1.07 (0.78, 1.47)] or reported injection drug use during follow-up [HR = 0.89 (0.66, 1.21)] compared with never injecting. In a separate multivariable-model, comparing women who reported no injection in past six months to active injection drug users, the frequency of injection during the previous six months measured by daily injection [HR = 0.97 (0.61, 1.55)] or less than daily injection [HR = 0.84 (0.54, 1.33)] was not associated with progression to AIDS. Being in drug treatment was independently associated with a slower progression to AIDS [HR = 0.41 (0.28, 0.59)]. Neither injection drug use, nor frequency of injection drug use was associated with progression to AIDS among HIV infected women. Initiation of antiretroviral therapy among drug users should be based on readiness for treatment rather than concern about faster progression.

AB - Data from a prospective, multi-centred study of HIV infection in women (HIV Epidemiology Research Study [HERS]) was analysed to investigate the effect of continued injection drug use behaviours on progression to AIDS. All women enrolled in the HERS had at enrolment and at six-month intervals, a face-to-face interview which included specific injection drug use, a physical exam, and specimen collection that included T-cell subset analysis and HIV plasma RNA detection. Six hundred and thirty-nine HIV-infected women contributed 3021 person years of observation during 7.25 years of follow-up, and 299 of these women progressed to AIDS (46.8%). In multivariable analysis, there was no significantly increased risk of progression to AIDS for women reporting pre-baseline injection drug use [hazard ratio (HR) = 1.07 (0.78, 1.47)] or reported injection drug use during follow-up [HR = 0.89 (0.66, 1.21)] compared with never injecting. In a separate multivariable-model, comparing women who reported no injection in past six months to active injection drug users, the frequency of injection during the previous six months measured by daily injection [HR = 0.97 (0.61, 1.55)] or less than daily injection [HR = 0.84 (0.54, 1.33)] was not associated with progression to AIDS. Being in drug treatment was independently associated with a slower progression to AIDS [HR = 0.41 (0.28, 0.59)]. Neither injection drug use, nor frequency of injection drug use was associated with progression to AIDS among HIV infected women. Initiation of antiretroviral therapy among drug users should be based on readiness for treatment rather than concern about faster progression.

KW - Drug use

KW - HIV progression

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=2442587319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442587319&partnerID=8YFLogxK

U2 - 10.1258/095646204323012814

DO - 10.1258/095646204323012814

M3 - Article

C2 - 15117502

AN - SCOPUS:2442587319

VL - 15

SP - 322

EP - 327

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

SN - 0956-4624

IS - 5

ER -