Evaluation of polylactic acid-carbon mesh for repair of ventral herniorrhaphy

Stuart M. Greenstein, Thomas F. Murphy, Benjamin F. Rush, Harold Alexander

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Large ventral hernias are a difficult surgical problem. Previous attempts to repair large defects in the abdominal wall with prostheses have been associated with recurrences and infection. A filamentous polylactic acid-carbon tissue mesh is a possible alternative prosthesis. We evaluated and compared polylactic acid-carbon mesh and Marlex mesh in repairing a large defect of the abdominal wall in a rat model. The polylactic acid-carbon mesh led to as strong a repair as Marlex mesh for the same time periods postoperatively; furthermore, no infection was noted with the former, whereas a 5.3 percent incidence of infection was noted with Marlex mesh. One mesh disruption was also noted with Marlex mesh. Polylactic acid-carbon mesh was found to have a more marked fibrotic response and a lesser inflammatory response. Polylactic acid-carbon mesh, therefore, appears to be more biocompatible, with more fibrosis, less inflammatory reaction, and equal strength to Marlex mesh. It is therefore a more appropriate synthetic material for a large ventral herniorrhaphy.

Original languageEnglish (US)
Pages (from-to)635-639
Number of pages5
JournalThe American Journal of Surgery
Volume151
Issue number5
DOIs
StatePublished - 1986
Externally publishedYes

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Polypropylenes
Herniorrhaphy
Carbon
Abdominal Wall
Prostheses and Implants
Infection
Ventral Hernia
Fibrosis
poly(lactic acid)
Recurrence
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Evaluation of polylactic acid-carbon mesh for repair of ventral herniorrhaphy. / Greenstein, Stuart M.; Murphy, Thomas F.; Rush, Benjamin F.; Alexander, Harold.

In: The American Journal of Surgery, Vol. 151, No. 5, 1986, p. 635-639.

Research output: Contribution to journalArticle

Greenstein, Stuart M. ; Murphy, Thomas F. ; Rush, Benjamin F. ; Alexander, Harold. / Evaluation of polylactic acid-carbon mesh for repair of ventral herniorrhaphy. In: The American Journal of Surgery. 1986 ; Vol. 151, No. 5. pp. 635-639.
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