TY - JOUR
T1 - Evaluation of polylactic acid-carbon mesh for repair of ventral herniorrhaphy
AU - Greenstein, Stuart M.
AU - Murphy, Thomas F.
AU - Rush, Benjamin F.
AU - Alexander, Harold
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1986/5
Y1 - 1986/5
N2 - Large ventral hernias are a difficult surgical problem. Previous attempts to repair large defects in the abdominal wall with prostheses have been associated with recurrences and infection. A filamentous polylactic acid-carbon tissue mesh is a possible alternative prosthesis. We evaluated and compared polylactic acid-carbon mesh and Marlex mesh in repairing a large defect of the abdominal wall in a rat model. The polylactic acid-carbon mesh led to as strong a repair as Marlex mesh for the same time periods postoperatively; furthermore, no infection was noted with the former, whereas a 5.3 percent incidence of infection was noted with Marlex mesh. One mesh disruption was also noted with Marlex mesh. Polylactic acid-carbon mesh was found to have a more marked fibrotic response and a lesser inflammatory response. Polylactic acid-carbon mesh, therefore, appears to be more biocompatible, with more fibrosis, less inflammatory reaction, and equal strength to Marlex mesh. It is therefore a more appropriate synthetic material for a large ventral herniorrhaphy.
AB - Large ventral hernias are a difficult surgical problem. Previous attempts to repair large defects in the abdominal wall with prostheses have been associated with recurrences and infection. A filamentous polylactic acid-carbon tissue mesh is a possible alternative prosthesis. We evaluated and compared polylactic acid-carbon mesh and Marlex mesh in repairing a large defect of the abdominal wall in a rat model. The polylactic acid-carbon mesh led to as strong a repair as Marlex mesh for the same time periods postoperatively; furthermore, no infection was noted with the former, whereas a 5.3 percent incidence of infection was noted with Marlex mesh. One mesh disruption was also noted with Marlex mesh. Polylactic acid-carbon mesh was found to have a more marked fibrotic response and a lesser inflammatory response. Polylactic acid-carbon mesh, therefore, appears to be more biocompatible, with more fibrosis, less inflammatory reaction, and equal strength to Marlex mesh. It is therefore a more appropriate synthetic material for a large ventral herniorrhaphy.
UR - http://www.scopus.com/inward/record.url?scp=0022548972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022548972&partnerID=8YFLogxK
U2 - 10.1016/0002-9610(86)90577-5
DO - 10.1016/0002-9610(86)90577-5
M3 - Article
C2 - 2939737
AN - SCOPUS:0022548972
SN - 0002-9610
VL - 151
SP - 635
EP - 639
JO - The American Journal of Surgery
JF - The American Journal of Surgery
IS - 5
ER -