TY - JOUR
T1 - Evaluation of Multimodality LAA Leak Closure Methods Following Incomplete Occlusion
T2 - The LAA Leak Study
AU - Charate, Rishi
AU - Ahmed, Adnan
AU - Della Rocca, Domenico G.
AU - Bloom, Stephen
AU - Garg, Jalaj
AU - Pothineni, Naga Venkata K.
AU - DiBiase, Luigi
AU - Turagam, Mohit
AU - Gopinathannair, Rakesh
AU - Horton, Rodney
AU - Kar, Saibal
AU - Fontana, Gregory
AU - Doshi, Shephal K.
AU - Swarup, Vijay
AU - Finn, Aloke
AU - Reddy, Vivek
AU - Natale, Andrea
AU - Lakkireddy, Dhanunjaya
N1 - Publisher Copyright:
© 2022 American College of Cardiology Foundation
PY - 2022/11/14
Y1 - 2022/11/14
N2 - Background: Incomplete left atrial appendage (LAA) closure is an evolving topic of clinical significance and thromboembolic potential, with recent long-term studies suggesting lower cutoffs for relevant leak size. Objectives: The aim of this prospective observational study was to assess 3 different closure techniques for persistent peridevice leaks after incomplete LAA closure and compare their efficacy and safety outcomes. Methods: We studied 160 patients (mean age 72 ± 9 years; 71% men) who underwent 1 of the 3 available modalities (detachable embolization coils, vascular plugs or septal occluders, and radiofrequency ablation) for residual central or eccentric leak closure. Both acute postprocedural success (closure or <1-mm leak at the end of the procedure) and closure at 1-year follow-up transesophageal echocardiography imaging were evaluated. Results: Of 160 patients, 0.6%, 41.3%, and 58.1% had mild (1-2 mm), moderate (3-5 mm), and severe (≥5 mm) leaks, respectively. Baseline LAA closure type was 72.5% Watchman FLX, 16.3% Lariat, 5.6% surgical ligation, 1.9% AtriClip, and 1.9% Amulet. Successful closure (0- or <1-mm leak) was seen in 100% of patients in all cohorts following intervention, with overall complete closure (0-1 mm) or mild or minimal leaks (1-2 mm) on 1-year follow-up transesophageal echocardiography seen in 100% of the atrial septal occluder or vascular plug cohort, 85.9% of the coil cohort, and 83.3% of the radiofrequency ablation cohort (P < 0.001). Two patients (1.3%) experienced cardiac tamponade, and there were no deaths or other complications. Conclusions: Peridevice leaks can safely and effectively be closed using 3 different modalities depending on size and location.
AB - Background: Incomplete left atrial appendage (LAA) closure is an evolving topic of clinical significance and thromboembolic potential, with recent long-term studies suggesting lower cutoffs for relevant leak size. Objectives: The aim of this prospective observational study was to assess 3 different closure techniques for persistent peridevice leaks after incomplete LAA closure and compare their efficacy and safety outcomes. Methods: We studied 160 patients (mean age 72 ± 9 years; 71% men) who underwent 1 of the 3 available modalities (detachable embolization coils, vascular plugs or septal occluders, and radiofrequency ablation) for residual central or eccentric leak closure. Both acute postprocedural success (closure or <1-mm leak at the end of the procedure) and closure at 1-year follow-up transesophageal echocardiography imaging were evaluated. Results: Of 160 patients, 0.6%, 41.3%, and 58.1% had mild (1-2 mm), moderate (3-5 mm), and severe (≥5 mm) leaks, respectively. Baseline LAA closure type was 72.5% Watchman FLX, 16.3% Lariat, 5.6% surgical ligation, 1.9% AtriClip, and 1.9% Amulet. Successful closure (0- or <1-mm leak) was seen in 100% of patients in all cohorts following intervention, with overall complete closure (0-1 mm) or mild or minimal leaks (1-2 mm) on 1-year follow-up transesophageal echocardiography seen in 100% of the atrial septal occluder or vascular plug cohort, 85.9% of the coil cohort, and 83.3% of the radiofrequency ablation cohort (P < 0.001). Two patients (1.3%) experienced cardiac tamponade, and there were no deaths or other complications. Conclusions: Peridevice leaks can safely and effectively be closed using 3 different modalities depending on size and location.
KW - atrial fibrillation
KW - central leaks
KW - leak closure
KW - left atrial appendage
KW - left atrial appendage closure
KW - peridevice leaks
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U2 - 10.1016/j.jcin.2022.08.034
DO - 10.1016/j.jcin.2022.08.034
M3 - Article
C2 - 36357020
AN - SCOPUS:85140914778
SN - 1936-8798
VL - 15
SP - 2158
EP - 2170
JO - JACC: Cardiovascular Interventions
JF - JACC: Cardiovascular Interventions
IS - 21
ER -