Evaluation of esterified hyaluronic acid as middle ear-packing material

Geming Li, Joseph G. Feghali, Elizabeth A. Dinces, John McElveen, Thomas R. Van De Water

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: To evaluate the efficacy of esterified hyaluronic acid (MeroGel) as a middle ear (ME)-packing material. Design: Randomized controlled trial. Material: Twenty-four guinea pigs. Intervention: Group 1, MeroGel-treated animals (n=10), bilateral wounding of ME mucosa with 5 of the animals receiving the MeroGel packing in the left ME and 5 of the animals receiving MeroGel in the right ME; group 2, absorbable gelatin sponge-treated animals (n=10), with the same experimental protocol as in group 1 except that the absorbable gelatin sponge was the packing material; group 3, untreated animals (n=4), unilateral wounding of the left ME mucosa in 2 animals and in 2 animals in the right ME, with no packing material. Auditory brainstem recordings were performed for all groups before the ME operation and 5 days and 6 weeks after the operation. Results: Auditory brainstem response recordings at postoperative day 5 showed that all ears with ME packing had hearing losses in the frequency range of 500 to 4000 Hz. The recovery of hearing acuity at postoperative week 6 was significantly better in group 1 (MeroGel-treated) guinea pigs compared with group 2 (the absorbable gelatin sponge-treated) animals. In group 2 animals, 20% of the packing material remained in the ME cavities and new bone formation was observed, while in group 1 animals, there was less packing material in the ME and no formation of new bone. Conclusions: MeroGel is a nonototoxic packing material with a high level of biocompatibility for ME mucosa; it is an effective supportive material following ME surgery and is easily expelled from the ME cavity.

Original languageEnglish (US)
Pages (from-to)534-539
Number of pages6
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume127
Issue number5
StatePublished - May 2001

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Middle Ear
Hyaluronic Acid
Absorbable Gelatin Sponge
Mucous Membrane
Osteogenesis
Guinea Pigs
Animal Rights
Brain Stem Auditory Evoked Potentials
Hearing Loss
Hearing
Brain Stem
Ear
Randomized Controlled Trials

ASJC Scopus subject areas

  • Otorhinolaryngology

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Evaluation of esterified hyaluronic acid as middle ear-packing material. / Li, Geming; Feghali, Joseph G.; Dinces, Elizabeth A.; McElveen, John; Van De Water, Thomas R.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 127, No. 5, 05.2001, p. 534-539.

Research output: Contribution to journalArticle

Li, G, Feghali, JG, Dinces, EA, McElveen, J & Van De Water, TR 2001, 'Evaluation of esterified hyaluronic acid as middle ear-packing material', Archives of Otolaryngology - Head and Neck Surgery, vol. 127, no. 5, pp. 534-539.
Li, Geming ; Feghali, Joseph G. ; Dinces, Elizabeth A. ; McElveen, John ; Van De Water, Thomas R. / Evaluation of esterified hyaluronic acid as middle ear-packing material. In: Archives of Otolaryngology - Head and Neck Surgery. 2001 ; Vol. 127, No. 5. pp. 534-539.
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