Evaluation of benzyl-substituted DTPA analogues as decorporation agents of radionuclides

Chi Soo Kang, Yunwei Chen, Ekaterina Dadachova, Hyun Soon Chong

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Optically active and racemic Bn-DTPA analogues were evaluated for potential decorporation of radioactive lanthanides. Complexation kinetics of the Bn-DTPA analogues with Sr(II), Ce(III), and Ce(IV) was measured using arsenazo III-based spectroscopic method. The Bn-DTPA analogues effectively and rapidly bound to Sr(II), Ce(III), and Ce(IV). Bn-DTPA was orally administered to mice and evaluated for decorporation of 85Sr and compared to that of the clinically available Ca(II)-DTPA. (rac)-Bn-DTPA removed 85Sr in mice more efficiently than DTPA. The Bn-DTPA analogues are promising decorporation agents for potential removal of 90Sr, 144Ce, and 141Ce.

Original languageEnglish (US)
Pages (from-to)2407-2411
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume303
Issue number3
DOIs
StatePublished - Jan 1 2015

Keywords

  • Ce
  • Ce
  • Chelating agents
  • DTPA
  • Decorporation of radionuclides
  • Sr

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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