Evaluation of benzyl-substituted DTPA analogues as decorporation agents of radionuclides

Chi Soo Kang; Yunwei Chen; Ekaterina Dadachova; Hyun Soon Chong

doi:10.1007/s10967-014-3714-9

Evaluation of benzyl-substituted DTPA analogues as decorporation agents of radionuclides

Chi Soo Kang, Yunwei Chen, Ekaterina Dadachova, Hyun Soon Chong

Radiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Optically active and racemic Bn-DTPA analogues were evaluated for potential decorporation of radioactive lanthanides. Complexation kinetics of the Bn-DTPA analogues with Sr(II), Ce(III), and Ce(IV) was measured using arsenazo III-based spectroscopic method. The Bn-DTPA analogues effectively and rapidly bound to Sr(II), Ce(III), and Ce(IV). Bn-DTPA was orally administered to mice and evaluated for decorporation of ⁸⁵Sr and compared to that of the clinically available Ca(II)-DTPA. (rac)-Bn-DTPA removed ⁸⁵Sr in mice more efficiently than DTPA. The Bn-DTPA analogues are promising decorporation agents for potential removal of ⁹⁰Sr, ¹⁴⁴Ce, and ¹⁴¹Ce.

Original language	English (US)
Pages (from-to)	2407-2411
Number of pages	5
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	303
Issue number	3
DOIs	https://doi.org/10.1007/s10967-014-3714-9
State	Published - 2015

Keywords

Ce
Ce
Chelating agents
DTPA
Decorporation of radionuclides
Sr

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10967-014-3714-9

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title = "Evaluation of benzyl-substituted DTPA analogues as decorporation agents of radionuclides",

abstract = "Optically active and racemic Bn-DTPA analogues were evaluated for potential decorporation of radioactive lanthanides. Complexation kinetics of the Bn-DTPA analogues with Sr(II), Ce(III), and Ce(IV) was measured using arsenazo III-based spectroscopic method. The Bn-DTPA analogues effectively and rapidly bound to Sr(II), Ce(III), and Ce(IV). Bn-DTPA was orally administered to mice and evaluated for decorporation of 85Sr and compared to that of the clinically available Ca(II)-DTPA. (rac)-Bn-DTPA removed 85Sr in mice more efficiently than DTPA. The Bn-DTPA analogues are promising decorporation agents for potential removal of 90Sr, 144Ce, and 141Ce.",

keywords = "Ce, Ce, Chelating agents, DTPA, Decorporation of radionuclides, Sr",

author = "Kang, {Chi Soo} and Yunwei Chen and Ekaterina Dadachova and Chong, {Hyun Soon}",

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year = "2015",

doi = "10.1007/s10967-014-3714-9",

language = "English (US)",

volume = "303",

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}

TY - JOUR

T1 - Evaluation of benzyl-substituted DTPA analogues as decorporation agents of radionuclides

AU - Kang, Chi Soo

AU - Chen, Yunwei

AU - Dadachova, Ekaterina

AU - Chong, Hyun Soon

PY - 2015

Y1 - 2015

N2 - Optically active and racemic Bn-DTPA analogues were evaluated for potential decorporation of radioactive lanthanides. Complexation kinetics of the Bn-DTPA analogues with Sr(II), Ce(III), and Ce(IV) was measured using arsenazo III-based spectroscopic method. The Bn-DTPA analogues effectively and rapidly bound to Sr(II), Ce(III), and Ce(IV). Bn-DTPA was orally administered to mice and evaluated for decorporation of 85Sr and compared to that of the clinically available Ca(II)-DTPA. (rac)-Bn-DTPA removed 85Sr in mice more efficiently than DTPA. The Bn-DTPA analogues are promising decorporation agents for potential removal of 90Sr, 144Ce, and 141Ce.

AB - Optically active and racemic Bn-DTPA analogues were evaluated for potential decorporation of radioactive lanthanides. Complexation kinetics of the Bn-DTPA analogues with Sr(II), Ce(III), and Ce(IV) was measured using arsenazo III-based spectroscopic method. The Bn-DTPA analogues effectively and rapidly bound to Sr(II), Ce(III), and Ce(IV). Bn-DTPA was orally administered to mice and evaluated for decorporation of 85Sr and compared to that of the clinically available Ca(II)-DTPA. (rac)-Bn-DTPA removed 85Sr in mice more efficiently than DTPA. The Bn-DTPA analogues are promising decorporation agents for potential removal of 90Sr, 144Ce, and 141Ce.

KW - Ce

KW - Chelating agents

KW - DTPA

KW - Decorporation of radionuclides

KW - Sr

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JF - Journal of Radioanalytical and Nuclear Chemistry

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ER -

Evaluation of benzyl-substituted DTPA analogues as decorporation agents of radionuclides

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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