Abstract
Here, we have investigated in vitro antimicrobial efficacy of a quaternized cationic polymer, poly[bis(2-chloroethyl)ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] (polyquaternium-2), against gram-positive as well as gram-negative bacteria along with several multi-drug-resistant bacterial strains. The antimicrobial efficacy of this polymer was first tested against some clinical pathogens followed by microorganisms isolated from acne lesions. Interestingly, polyquaternium-2 exhibited significant antimicrobial activity against methicillin-resistant Staphylococcus aureus, for which very limited drugs are available. Most importantly, the polymer displayed low haemolytic activity and non-toxic behaviour against mammalian cells. The results showed the promising potential of the projected polymer to be utilized as an antibacterial agent for various biomedical applications.
Original language | English (US) |
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Pages (from-to) | 467-480 |
Number of pages | 14 |
Journal | Journal of Bioactive and Compatible Polymers |
Volume | 31 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1 2016 |
Externally published | Yes |
Keywords
- Quaternized polymer
- antimicrobial activity
- cytotoxicity
- haemolysis
- multi-drug resistance
- transmission electron microscopy
ASJC Scopus subject areas
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry