Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models

E. Dadachova, R. A. Bryan, A. Frenkel, T. Zhang, C. Apostolidis, S. Nosanchuk, Joshua D. Nosanchuk, A. Casadevall

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 μCi were well tolerated by healthy A/JCr mice for 213Bi-18B7 and 188Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 μCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.

Original languageEnglish (US)
Pages (from-to)1004-1006
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number3
DOIs
StatePublished - Mar 2004

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Radioimmunotherapy
Cryptococcus neoformans
Lung
Infection
Radiation Pneumonitis
Monoclonal Antibodies

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models. / Dadachova, E.; Bryan, R. A.; Frenkel, A.; Zhang, T.; Apostolidis, C.; Nosanchuk, S.; Nosanchuk, Joshua D.; Casadevall, A.

In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 3, 03.2004, p. 1004-1006.

Research output: Contribution to journalArticle

Dadachova, E. ; Bryan, R. A. ; Frenkel, A. ; Zhang, T. ; Apostolidis, C. ; Nosanchuk, S. ; Nosanchuk, Joshua D. ; Casadevall, A. / Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models. In: Antimicrobial Agents and Chemotherapy. 2004 ; Vol. 48, No. 3. pp. 1004-1006.
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