Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models

E. Dadachova; R. A. Bryan; A. Frenkel; T. Zhang; C. Apostolidis; S. Nosanchuk; J. D. Nosanchuk; A. Casadevall

doi:10.1128/AAC.48.3.1004-1006.2004

Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models

E. Dadachova, R. A. Bryan, A. Frenkel, T. Zhang, C. Apostolidis, S. Nosanchuk, J. D. Nosanchuk, A. Casadevall

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Abstract

We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 μCi were well tolerated by healthy A/JCr mice for ²¹³Bi-18B7 and ¹⁸⁸Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 μCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.

Original language	English (US)
Pages (from-to)	1004-1006
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	48
Issue number	3
DOIs	https://doi.org/10.1128/AAC.48.3.1004-1006.2004
State	Published - Mar 2004

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.48.3.1004-1006.2004

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Dadachova, E., Bryan, R. A., Frenkel, A., Zhang, T., Apostolidis, C., Nosanchuk, S., Nosanchuk, J. D., & Casadevall, A. (2004). Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models. Antimicrobial agents and chemotherapy, 48(3), 1004-1006. https://doi.org/10.1128/AAC.48.3.1004-1006.2004

Dadachova, E, Bryan, RA, Frenkel, A, Zhang, T, Apostolidis, C, Nosanchuk, S, Nosanchuk, JD & Casadevall, A 2004, 'Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models', Antimicrobial agents and chemotherapy, vol. 48, no. 3, pp. 1004-1006. https://doi.org/10.1128/AAC.48.3.1004-1006.2004

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Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models

Abstract

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