TY - JOUR
T1 - Evaluation of a prototype real-time PCR assay for carcinogenic human papillomavirus (HPV) detection and simultaneous HPV genotype 16 (HPV16) and HPV18 genotyping
AU - Castle, Philip E.
AU - Sadorra, Mark
AU - Lau, Tiffany
AU - Aldrich, Carrie
AU - Garcia, Francisco A.R.
AU - Kornegay, Janet
PY - 2009/10
Y1 - 2009/10
N2 - Results from a prototype real-time PCR assay that separately detected human papillomavirus genotype 16 (HPV16), HPV18, and 12 other carcinogenic HPV genotypes in aggregate (cobas 4800 HPV test) and results from a PCR assay that detects 37 HPV genotypes individually (Linear Array) were compared using a convenience sample of cervical specimens (n = 531). The percentage of total agreement between the two assays was 94.7% (95% confidence interval, 92.5 to 96.5%). The Linear Array test was more likely than cobas 4800 HPV test to test positive for the 12 other carcinogenic HPV genotypes among women without evidence of cervical disease (P = 0.004).
AB - Results from a prototype real-time PCR assay that separately detected human papillomavirus genotype 16 (HPV16), HPV18, and 12 other carcinogenic HPV genotypes in aggregate (cobas 4800 HPV test) and results from a PCR assay that detects 37 HPV genotypes individually (Linear Array) were compared using a convenience sample of cervical specimens (n = 531). The percentage of total agreement between the two assays was 94.7% (95% confidence interval, 92.5 to 96.5%). The Linear Array test was more likely than cobas 4800 HPV test to test positive for the 12 other carcinogenic HPV genotypes among women without evidence of cervical disease (P = 0.004).
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U2 - 10.1128/JCM.00725-09
DO - 10.1128/JCM.00725-09
M3 - Article
C2 - 19675214
AN - SCOPUS:70349648503
SN - 0095-1137
VL - 47
SP - 3344
EP - 3347
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 10
ER -
