Evaluation and management of steroid-unresponsive nephrotic syndrome

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Idiopathic nephrotic syndrome in children is commonly associated with minimal change disease and response to steroid therapy. Steroid-unresponsive nephrotic syndrome is often characterized by persistent proteinuria and progression to chronic kidney disease. Focal segmental glomerulosclerosis is the leading cause of steroid-unresponsive nephrotic syndrome in childhood. There is no uniformed consensus as to the treatment of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis, genetics and biomarkers or surrogate markers may be useful for the diagnosis and identification of patients with steroid-unresponsive nephrotic syndrome, severity of disease, progression and response to therapy. RECENT FINDINGS: This review is intended to describe some of the recent changes in the epidemiology of steroid-unresponsive nephrotic syndrome, in particular focal segmental glomerulosclerosis, its pathogenesis and alternative therapies. SUMMARY: Recent studies in both children and adults have shown an increase in the incidence of focal segmental sclerosis as a cause of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis and noninvasive methods of diagnosis may allow for the identification of steroid-responsive patients.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalCurrent Opinion in Pediatrics
Volume20
Issue number2
DOIs
StatePublished - Apr 2008

Fingerprint

Nephrotic Syndrome
Steroids
Focal Segmental Glomerulosclerosis
Biomarkers
Lipoid Nephrosis
Sclerosis
Complementary Therapies
Chronic Renal Insufficiency
Genetic Markers
Proteinuria
Disease Progression
Epidemiology
Therapeutics
Incidence

Keywords

  • Focal segmental glomerulosclerosis
  • Nephrotic syndrome
  • Steroid-resistant nephrotic syndrome
  • Steroid-sensitive nephrotic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Evaluation and management of steroid-unresponsive nephrotic syndrome. / Del Rio, Marcela; Kaskel, Frederick J.

In: Current Opinion in Pediatrics, Vol. 20, No. 2, 04.2008, p. 151-156.

Research output: Contribution to journalArticle

@article{63c437f292fd4b92a5445ec169cec52b,
title = "Evaluation and management of steroid-unresponsive nephrotic syndrome",
abstract = "PURPOSE OF REVIEW: Idiopathic nephrotic syndrome in children is commonly associated with minimal change disease and response to steroid therapy. Steroid-unresponsive nephrotic syndrome is often characterized by persistent proteinuria and progression to chronic kidney disease. Focal segmental glomerulosclerosis is the leading cause of steroid-unresponsive nephrotic syndrome in childhood. There is no uniformed consensus as to the treatment of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis, genetics and biomarkers or surrogate markers may be useful for the diagnosis and identification of patients with steroid-unresponsive nephrotic syndrome, severity of disease, progression and response to therapy. RECENT FINDINGS: This review is intended to describe some of the recent changes in the epidemiology of steroid-unresponsive nephrotic syndrome, in particular focal segmental glomerulosclerosis, its pathogenesis and alternative therapies. SUMMARY: Recent studies in both children and adults have shown an increase in the incidence of focal segmental sclerosis as a cause of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis and noninvasive methods of diagnosis may allow for the identification of steroid-responsive patients.",
keywords = "Focal segmental glomerulosclerosis, Nephrotic syndrome, Steroid-resistant nephrotic syndrome, Steroid-sensitive nephrotic syndrome",
author = "{Del Rio}, Marcela and Kaskel, {Frederick J.}",
year = "2008",
month = "4",
doi = "10.1097/MOP.0b013e3282f4e6e4",
language = "English (US)",
volume = "20",
pages = "151--156",
journal = "Current Opinion in Pediatrics",
issn = "1040-8703",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Evaluation and management of steroid-unresponsive nephrotic syndrome

AU - Del Rio, Marcela

AU - Kaskel, Frederick J.

PY - 2008/4

Y1 - 2008/4

N2 - PURPOSE OF REVIEW: Idiopathic nephrotic syndrome in children is commonly associated with minimal change disease and response to steroid therapy. Steroid-unresponsive nephrotic syndrome is often characterized by persistent proteinuria and progression to chronic kidney disease. Focal segmental glomerulosclerosis is the leading cause of steroid-unresponsive nephrotic syndrome in childhood. There is no uniformed consensus as to the treatment of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis, genetics and biomarkers or surrogate markers may be useful for the diagnosis and identification of patients with steroid-unresponsive nephrotic syndrome, severity of disease, progression and response to therapy. RECENT FINDINGS: This review is intended to describe some of the recent changes in the epidemiology of steroid-unresponsive nephrotic syndrome, in particular focal segmental glomerulosclerosis, its pathogenesis and alternative therapies. SUMMARY: Recent studies in both children and adults have shown an increase in the incidence of focal segmental sclerosis as a cause of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis and noninvasive methods of diagnosis may allow for the identification of steroid-responsive patients.

AB - PURPOSE OF REVIEW: Idiopathic nephrotic syndrome in children is commonly associated with minimal change disease and response to steroid therapy. Steroid-unresponsive nephrotic syndrome is often characterized by persistent proteinuria and progression to chronic kidney disease. Focal segmental glomerulosclerosis is the leading cause of steroid-unresponsive nephrotic syndrome in childhood. There is no uniformed consensus as to the treatment of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis, genetics and biomarkers or surrogate markers may be useful for the diagnosis and identification of patients with steroid-unresponsive nephrotic syndrome, severity of disease, progression and response to therapy. RECENT FINDINGS: This review is intended to describe some of the recent changes in the epidemiology of steroid-unresponsive nephrotic syndrome, in particular focal segmental glomerulosclerosis, its pathogenesis and alternative therapies. SUMMARY: Recent studies in both children and adults have shown an increase in the incidence of focal segmental sclerosis as a cause of steroid-unresponsive nephrotic syndrome. Advances in the pathogenesis and noninvasive methods of diagnosis may allow for the identification of steroid-responsive patients.

KW - Focal segmental glomerulosclerosis

KW - Nephrotic syndrome

KW - Steroid-resistant nephrotic syndrome

KW - Steroid-sensitive nephrotic syndrome

UR - http://www.scopus.com/inward/record.url?scp=40549137748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549137748&partnerID=8YFLogxK

U2 - 10.1097/MOP.0b013e3282f4e6e4

DO - 10.1097/MOP.0b013e3282f4e6e4

M3 - Article

VL - 20

SP - 151

EP - 156

JO - Current Opinion in Pediatrics

JF - Current Opinion in Pediatrics

SN - 1040-8703

IS - 2

ER -