ETV6 mutations in early immature human T cell leukemias

Pieter Van Vlierberghe, Alberto Ambesi-Impiombato, Arianne Perez-Garcia, J. Erika Haydu, Isaura Rigo, Michael Hadler, Valeria Tosello, Giusy Della Gatta, Elisabeth Paietta, Janis Racevskis, Peter H. Wiernik, Selina M. Luger, Jacob M. Rowe, Montserrat Rue, Adolfo A. Ferrando

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for ~5.10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relationship between these tumors and myeloid leukemias. Many adult immature T-ALLs harbored mutations in myeloid-specific oncogenes and tumor suppressors including IDH1, IDH2, DNMT3A, FLT3, and NRAS. Moreover, we identified ETV6 mutations as a novel genetic lesion uniquely present in immature adult T-ALL. Our results demonstrate that early immature adult T-ALL represents a heterogeneous category of leukemias characterized by the presence of overlapping myeloid and T-ALL characteristics, and highlight the potential role of ETV6 mutations in these tumors.

Original languageEnglish (US)
Pages (from-to)2571-2579
Number of pages9
JournalJournal of Experimental Medicine
Volume208
Issue number13
DOIs
StatePublished - Dec 19 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Vlierberghe, P. V., Ambesi-Impiombato, A., Perez-Garcia, A., Haydu, J. E., Rigo, I., Hadler, M., Tosello, V., Gatta, G. D., Paietta, E., Racevskis, J., Wiernik, P. H., Luger, S. M., Rowe, J. M., Rue, M., & Ferrando, A. A. (2011). ETV6 mutations in early immature human T cell leukemias. Journal of Experimental Medicine, 208(13), 2571-2579. https://doi.org/10.1084/jem.20112239