ETO2-GLIS2: A Chimeric Transcription Factor Drives Leukemogenesis through a Neomorphic Transcription Network

Justin C. Wheat, Ulrich G. Steidl

Research output: Contribution to journalShort survey

Abstract

Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease with a relatively poorly understood pathogenesis. In this issue of Cancer Cell, Thirant and colleagues systematically examine unique transcriptional and functional effects of ETO2-GLIS2, an oncogenic fusion protein frequently encountered in AMKL, and elucidate a therapeutic vulnerability in this poor-prognosis leukemia.

Original languageEnglish (US)
Pages (from-to)307-308
Number of pages2
JournalCancer Cell
Volume31
Issue number3
DOIs
StatePublished - Mar 13 2017

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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