Abstract
OBJECTIVE: The purpose of this study was to compare gestational trophoblastic disease incidence rates with the use of population-based data. STUDY DESIGN: All incident cases between 1973 and 1997 and live birth, pregnancy, and women at risk were tabulated with the use of data that were derived from the New Mexico Tumor Registry and Vital Records and Health Statistics Annual Reports. Statistical methods included trends analyses, odds ratios, and Poisson regression. RESULTS: Of 939 total cases, 312 non-Hispanic white women, 399 Hispanic white women, 201 American Indian women, and 27 other women were affected. Age-adjusted incidence rates were significantly higher for American Indian women (11.16%) compared with non-Hispanic (3.57%) or Hispanic white women (5.32%); the probability value was <.001. When live birth (1:438 women) and pregnancy (1:486 women) denominators were considered, American Indian women alone were at increased risk, and the ratio increased by 56% over 25 years. American Indian women were also at increased risk for partial mole (relative risk, 4.03; 95% Cl, 2.57-6.31), invasive mole (relative risk, 26.7; 95% Cl, 7.81-93.14), and choriocarcinoma (relative risk, 6.29; 95% Cl, 1.81-22.66) variants. CONCLUSION: American Indians are at increased risk relative to the other predominant ethnic groups in New Mexico. Age-adjusted standardization provided a reproducible measurement that may be applicable across other registries.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-366 |
| Number of pages | 10 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 188 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2003 |
| Externally published | Yes |
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Keywords
- Age-adjusted incidence rate
- American Indian
- Gestational trophoblastic disease
- Hispanic white woman
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Ethnic differences at risk for gestational trophoblastic disease in New Mexico : A 25-year population-based study. / Smith, Harriet O.; Hilgers, Robert D.; Bedrick, Edward J.; Qualls, Clifford R.; Wiggins, Charles L.; Rayburn, William F.; Waxman, Alan G.; Stephens, Nicole D.; Cole, Laurence W.; Swanson, Marian; Key, Charles R.
In: American Journal of Obstetrics and Gynecology, Vol. 188, No. 2, 01.02.2003, p. 357-366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ethnic differences at risk for gestational trophoblastic disease in New Mexico
T2 - A 25-year population-based study
AU - Smith, Harriet O.
AU - Hilgers, Robert D.
AU - Bedrick, Edward J.
AU - Qualls, Clifford R.
AU - Wiggins, Charles L.
AU - Rayburn, William F.
AU - Waxman, Alan G.
AU - Stephens, Nicole D.
AU - Cole, Laurence W.
AU - Swanson, Marian
AU - Key, Charles R.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - OBJECTIVE: The purpose of this study was to compare gestational trophoblastic disease incidence rates with the use of population-based data. STUDY DESIGN: All incident cases between 1973 and 1997 and live birth, pregnancy, and women at risk were tabulated with the use of data that were derived from the New Mexico Tumor Registry and Vital Records and Health Statistics Annual Reports. Statistical methods included trends analyses, odds ratios, and Poisson regression. RESULTS: Of 939 total cases, 312 non-Hispanic white women, 399 Hispanic white women, 201 American Indian women, and 27 other women were affected. Age-adjusted incidence rates were significantly higher for American Indian women (11.16%) compared with non-Hispanic (3.57%) or Hispanic white women (5.32%); the probability value was <.001. When live birth (1:438 women) and pregnancy (1:486 women) denominators were considered, American Indian women alone were at increased risk, and the ratio increased by 56% over 25 years. American Indian women were also at increased risk for partial mole (relative risk, 4.03; 95% Cl, 2.57-6.31), invasive mole (relative risk, 26.7; 95% Cl, 7.81-93.14), and choriocarcinoma (relative risk, 6.29; 95% Cl, 1.81-22.66) variants. CONCLUSION: American Indians are at increased risk relative to the other predominant ethnic groups in New Mexico. Age-adjusted standardization provided a reproducible measurement that may be applicable across other registries.
AB - OBJECTIVE: The purpose of this study was to compare gestational trophoblastic disease incidence rates with the use of population-based data. STUDY DESIGN: All incident cases between 1973 and 1997 and live birth, pregnancy, and women at risk were tabulated with the use of data that were derived from the New Mexico Tumor Registry and Vital Records and Health Statistics Annual Reports. Statistical methods included trends analyses, odds ratios, and Poisson regression. RESULTS: Of 939 total cases, 312 non-Hispanic white women, 399 Hispanic white women, 201 American Indian women, and 27 other women were affected. Age-adjusted incidence rates were significantly higher for American Indian women (11.16%) compared with non-Hispanic (3.57%) or Hispanic white women (5.32%); the probability value was <.001. When live birth (1:438 women) and pregnancy (1:486 women) denominators were considered, American Indian women alone were at increased risk, and the ratio increased by 56% over 25 years. American Indian women were also at increased risk for partial mole (relative risk, 4.03; 95% Cl, 2.57-6.31), invasive mole (relative risk, 26.7; 95% Cl, 7.81-93.14), and choriocarcinoma (relative risk, 6.29; 95% Cl, 1.81-22.66) variants. CONCLUSION: American Indians are at increased risk relative to the other predominant ethnic groups in New Mexico. Age-adjusted standardization provided a reproducible measurement that may be applicable across other registries.
KW - Age-adjusted incidence rate
KW - American Indian
KW - Gestational trophoblastic disease
KW - Hispanic white woman
UR - http://www.scopus.com/inward/record.url?scp=0037325217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037325217&partnerID=8YFLogxK
U2 - 10.1067/mob.2003.39
DO - 10.1067/mob.2003.39
M3 - Article
C2 - 12592240
AN - SCOPUS:0037325217
VL - 188
SP - 357
EP - 366
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -