Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy

Jessica A. Cohen; Anna C. Mastroianni; Ruth Macklin

doi:10.1016/j.ijgo.2014.07.012

Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy

Jessica A. Cohen, Anna C. Mastroianni, Ruth Macklin

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.

Original language	English (US)
Pages (from-to)	221-224
Number of pages	4
Journal	International Journal of Gynecology and Obstetrics
Volume	127
Issue number	2
DOIs	https://doi.org/10.1016/j.ijgo.2014.07.012
State	Published - Nov 1 2014
Externally published	Yes

Keywords

Ethics
HIV prevention
Multipurpose prevention technologies
Pregnancy prevention

ASJC Scopus subject areas

Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijgo.2014.07.012

Cite this

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title = "Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy",

abstract = "Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.",

keywords = "Ethics, HIV prevention, Multipurpose prevention technologies, Pregnancy prevention",

author = "Cohen, {Jessica A.} and Mastroianni, {Anna C.} and Ruth Macklin",

note = "Funding Information: Jessica Cohen{\textquoteright}s work was supported by the United States Agency for International Development (USAID) under the terms of the HealthTech Cooperative Agreement # AID-OAA-A-11-00051 . The contents are the responsibility of PATH and other authors, and do not necessarily reflect the views of USAID or the United States Government. Anna Mastroianni{\textquoteright}s work was supported by the National Institutes of Health (NIH Grant no. 1 R56 AI108368-01 ). Publisher Copyright: {\textcopyright} 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.",

year = "2014",

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doi = "10.1016/j.ijgo.2014.07.012",

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AU - Macklin, Ruth

N1 - Funding Information: Jessica Cohen’s work was supported by the United States Agency for International Development (USAID) under the terms of the HealthTech Cooperative Agreement # AID-OAA-A-11-00051 . The contents are the responsibility of PATH and other authors, and do not necessarily reflect the views of USAID or the United States Government. Anna Mastroianni’s work was supported by the National Institutes of Health (NIH Grant no. 1 R56 AI108368-01 ). Publisher Copyright: © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

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AB - Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.

KW - Ethics

KW - HIV prevention

KW - Multipurpose prevention technologies

KW - Pregnancy prevention

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Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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