Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy

Jessica A. Cohen, Anna C. Mastroianni, Ruth Macklin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume127
Issue number2
DOIs
StatePublished - Nov 1 2014

Fingerprint

Ethics
Reproductive Health
HIV
Technology
Pregnancy
Contraceptive Agents
Research
Clinical Trials

Keywords

  • Ethics
  • HIV prevention
  • Multipurpose prevention technologies
  • Pregnancy prevention

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy. / Cohen, Jessica A.; Mastroianni, Anna C.; Macklin, Ruth.

In: International Journal of Gynecology and Obstetrics, Vol. 127, No. 2, 01.11.2014, p. 221-224.

Research output: Contribution to journalArticle

Cohen, Jessica A. ; Mastroianni, Anna C. ; Macklin, Ruth. / Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy. In: International Journal of Gynecology and Obstetrics. 2014 ; Vol. 127, No. 2. pp. 221-224.
@article{ce49ed1ff271470b9ef198ce5b5c25d1,
title = "Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy",
abstract = "Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.",
keywords = "Ethics, HIV prevention, Multipurpose prevention technologies, Pregnancy prevention",
author = "Cohen, {Jessica A.} and Mastroianni, {Anna C.} and Ruth Macklin",
year = "2014",
month = "11",
day = "1",
doi = "10.1016/j.ijgo.2014.07.012",
language = "English (US)",
volume = "127",
pages = "221--224",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Ethical issues for late-stage trials of multipurpose prevention technologies for HIV and pregnancy

AU - Cohen, Jessica A.

AU - Mastroianni, Anna C.

AU - Macklin, Ruth

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.

AB - Multipurpose prevention technologies (MPTs) designed to simultaneously prevent pregnancy and HIV could provide urgently needed tools to address unmet sexual and reproductive health needs of women worldwide. Late-stage clinical trials will be complex given the need to demonstrate efficacy for HIV and contraceptive indications simultaneously from a single product. Currently, HIV and pregnancy prevention trials have distinctive design features that will need to be reconciled in MPT trials. This article identifies several ethical issues uniquely associated with this research that will benefit from future deliberation and guidance to ensure that this globally important research can proceed efficiently and expeditiously.

KW - Ethics

KW - HIV prevention

KW - Multipurpose prevention technologies

KW - Pregnancy prevention

UR - http://www.scopus.com/inward/record.url?scp=84908058304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908058304&partnerID=8YFLogxK

U2 - 10.1016/j.ijgo.2014.07.012

DO - 10.1016/j.ijgo.2014.07.012

M3 - Article

AN - SCOPUS:84908058304

VL - 127

SP - 221

EP - 224

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

IS - 2

ER -