Ethanol

Relative fuel value and metabolic effects in vivo

John F. Reinus, Steven B. Heymsfield, Robert Wiskind, Katie Casper, John T. Galambos

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

A nasogastric formula infusion method was used to evaluate the steady-state fuel value of ethanol relative to that of glucose in eight chronically alcoholic men undergoing a 4- or 5-week balance experiment. Each subject received a maintenance infusion of the formula diet throughout the study. When control formula glucose (week 1) was isocalorically replaced with ethanol [week 2, 30% of kcal; week 3 or 4 (5-week experiment) 40% to 60% of kcal], the following was observed: weight loss; zero energy balance and reduced or negative balances of N, K, P, Mg, and Na; increased urinary urea N and 3-methylhistidine; lowered urinary C-peptide; no change in indirectly or directly measured thermal energy losses; and a blood level related rise in breath and urinary ethanol losses. All of these changes promptly reversed during the middle (week 3 in 5-week experiment) and final control weeks. Accounting for all diet-related energy losses (urine, breath, thermal), the fuel value of the ethanol-containing diet relative to the glucose control formula varied between 0.95 and 0.99, depending upon the blood alcohol level. Hence weight loss during short-term (seven-day) ethanol infusion is unrelated to overall negative energy balance, stems primarily from decrements in protein, minerals, and fluid, and may in part be mediated by the reduction in insulin secretion that accompanies switching from dietary glucose to ethanol.

Original languageEnglish (US)
Pages (from-to)125-135
Number of pages11
JournalMetabolism
Volume38
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Ethanol
Glucose
Weight Loss
Hot Temperature
Diet
Formulated Food
C-Peptide
Alcoholics
Minerals
Urea
Maintenance
Urine
Insulin
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Reinus, J. F., Heymsfield, S. B., Wiskind, R., Casper, K., & Galambos, J. T. (1989). Ethanol: Relative fuel value and metabolic effects in vivo. Metabolism, 38(2), 125-135. https://doi.org/10.1016/0026-0495(89)90251-5

Ethanol : Relative fuel value and metabolic effects in vivo. / Reinus, John F.; Heymsfield, Steven B.; Wiskind, Robert; Casper, Katie; Galambos, John T.

In: Metabolism, Vol. 38, No. 2, 1989, p. 125-135.

Research output: Contribution to journalArticle

Reinus, JF, Heymsfield, SB, Wiskind, R, Casper, K & Galambos, JT 1989, 'Ethanol: Relative fuel value and metabolic effects in vivo', Metabolism, vol. 38, no. 2, pp. 125-135. https://doi.org/10.1016/0026-0495(89)90251-5
Reinus, John F. ; Heymsfield, Steven B. ; Wiskind, Robert ; Casper, Katie ; Galambos, John T. / Ethanol : Relative fuel value and metabolic effects in vivo. In: Metabolism. 1989 ; Vol. 38, No. 2. pp. 125-135.
@article{2e178fd5ab3146578260cb5572a9bf17,
title = "Ethanol: Relative fuel value and metabolic effects in vivo",
abstract = "A nasogastric formula infusion method was used to evaluate the steady-state fuel value of ethanol relative to that of glucose in eight chronically alcoholic men undergoing a 4- or 5-week balance experiment. Each subject received a maintenance infusion of the formula diet throughout the study. When control formula glucose (week 1) was isocalorically replaced with ethanol [week 2, 30{\%} of kcal; week 3 or 4 (5-week experiment) 40{\%} to 60{\%} of kcal], the following was observed: weight loss; zero energy balance and reduced or negative balances of N, K, P, Mg, and Na; increased urinary urea N and 3-methylhistidine; lowered urinary C-peptide; no change in indirectly or directly measured thermal energy losses; and a blood level related rise in breath and urinary ethanol losses. All of these changes promptly reversed during the middle (week 3 in 5-week experiment) and final control weeks. Accounting for all diet-related energy losses (urine, breath, thermal), the fuel value of the ethanol-containing diet relative to the glucose control formula varied between 0.95 and 0.99, depending upon the blood alcohol level. Hence weight loss during short-term (seven-day) ethanol infusion is unrelated to overall negative energy balance, stems primarily from decrements in protein, minerals, and fluid, and may in part be mediated by the reduction in insulin secretion that accompanies switching from dietary glucose to ethanol.",
author = "Reinus, {John F.} and Heymsfield, {Steven B.} and Robert Wiskind and Katie Casper and Galambos, {John T.}",
year = "1989",
doi = "10.1016/0026-0495(89)90251-5",
language = "English (US)",
volume = "38",
pages = "125--135",
journal = "Metabolism: Clinical and Experimental",
issn = "0026-0495",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Ethanol

T2 - Relative fuel value and metabolic effects in vivo

AU - Reinus, John F.

AU - Heymsfield, Steven B.

AU - Wiskind, Robert

AU - Casper, Katie

AU - Galambos, John T.

PY - 1989

Y1 - 1989

N2 - A nasogastric formula infusion method was used to evaluate the steady-state fuel value of ethanol relative to that of glucose in eight chronically alcoholic men undergoing a 4- or 5-week balance experiment. Each subject received a maintenance infusion of the formula diet throughout the study. When control formula glucose (week 1) was isocalorically replaced with ethanol [week 2, 30% of kcal; week 3 or 4 (5-week experiment) 40% to 60% of kcal], the following was observed: weight loss; zero energy balance and reduced or negative balances of N, K, P, Mg, and Na; increased urinary urea N and 3-methylhistidine; lowered urinary C-peptide; no change in indirectly or directly measured thermal energy losses; and a blood level related rise in breath and urinary ethanol losses. All of these changes promptly reversed during the middle (week 3 in 5-week experiment) and final control weeks. Accounting for all diet-related energy losses (urine, breath, thermal), the fuel value of the ethanol-containing diet relative to the glucose control formula varied between 0.95 and 0.99, depending upon the blood alcohol level. Hence weight loss during short-term (seven-day) ethanol infusion is unrelated to overall negative energy balance, stems primarily from decrements in protein, minerals, and fluid, and may in part be mediated by the reduction in insulin secretion that accompanies switching from dietary glucose to ethanol.

AB - A nasogastric formula infusion method was used to evaluate the steady-state fuel value of ethanol relative to that of glucose in eight chronically alcoholic men undergoing a 4- or 5-week balance experiment. Each subject received a maintenance infusion of the formula diet throughout the study. When control formula glucose (week 1) was isocalorically replaced with ethanol [week 2, 30% of kcal; week 3 or 4 (5-week experiment) 40% to 60% of kcal], the following was observed: weight loss; zero energy balance and reduced or negative balances of N, K, P, Mg, and Na; increased urinary urea N and 3-methylhistidine; lowered urinary C-peptide; no change in indirectly or directly measured thermal energy losses; and a blood level related rise in breath and urinary ethanol losses. All of these changes promptly reversed during the middle (week 3 in 5-week experiment) and final control weeks. Accounting for all diet-related energy losses (urine, breath, thermal), the fuel value of the ethanol-containing diet relative to the glucose control formula varied between 0.95 and 0.99, depending upon the blood alcohol level. Hence weight loss during short-term (seven-day) ethanol infusion is unrelated to overall negative energy balance, stems primarily from decrements in protein, minerals, and fluid, and may in part be mediated by the reduction in insulin secretion that accompanies switching from dietary glucose to ethanol.

UR - http://www.scopus.com/inward/record.url?scp=0024494719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024494719&partnerID=8YFLogxK

U2 - 10.1016/0026-0495(89)90251-5

DO - 10.1016/0026-0495(89)90251-5

M3 - Article

VL - 38

SP - 125

EP - 135

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

SN - 0026-0495

IS - 2

ER -