TY - JOUR
T1 - Ethanol
T2 - Relative fuel value and metabolic effects in vivo
AU - Reinus, John F.
AU - Heymsfield, Steven B.
AU - Wiskind, Robert
AU - Casper, Katie
AU - Galambos, John T.
N1 - Funding Information:
From the Divisions of Endocrinology/Metabolism and Gastroenterology, Department of Medicine, Emory University School of Medicine, Atlanta, GA. .t.F. Reinus is currently a$Ziated with the Division of Gastroenterology, Montefiore Hospital, Bronx, NY. Supported by NIH Grant No. RR0039 and a grant from the Alcoholic Beverage Medical Research Foundation, Address reprint requests to Steven B. Heymsfield, MD, Obesity Research Center, St. Luke’s_Roosevelt Hospital Center, 114th St and Amsterdam Ave. New York, NY 10025. o 1989 by Grune & Stratton, Inc. 00260495/89/3802-0007$03.00/O
PY - 1989/2
Y1 - 1989/2
N2 - A nasogastric formula infusion method was used to evaluate the steady-state fuel value of ethanol relative to that of glucose in eight chronically alcoholic men undergoing a 4- or 5-week balance experiment. Each subject received a maintenance infusion of the formula diet throughout the study. When control formula glucose (week 1) was isocalorically replaced with ethanol [week 2, 30% of kcal; week 3 or 4 (5-week experiment) 40% to 60% of kcal], the following was observed: weight loss; zero energy balance and reduced or negative balances of N, K, P, Mg, and Na; increased urinary urea N and 3-methylhistidine; lowered urinary C-peptide; no change in indirectly or directly measured thermal energy losses; and a blood level related rise in breath and urinary ethanol losses. All of these changes promptly reversed during the middle (week 3 in 5-week experiment) and final control weeks. Accounting for all diet-related energy losses (urine, breath, thermal), the fuel value of the ethanol-containing diet relative to the glucose control formula varied between 0.95 and 0.99, depending upon the blood alcohol level. Hence weight loss during short-term (seven-day) ethanol infusion is unrelated to overall negative energy balance, stems primarily from decrements in protein, minerals, and fluid, and may in part be mediated by the reduction in insulin secretion that accompanies switching from dietary glucose to ethanol.
AB - A nasogastric formula infusion method was used to evaluate the steady-state fuel value of ethanol relative to that of glucose in eight chronically alcoholic men undergoing a 4- or 5-week balance experiment. Each subject received a maintenance infusion of the formula diet throughout the study. When control formula glucose (week 1) was isocalorically replaced with ethanol [week 2, 30% of kcal; week 3 or 4 (5-week experiment) 40% to 60% of kcal], the following was observed: weight loss; zero energy balance and reduced or negative balances of N, K, P, Mg, and Na; increased urinary urea N and 3-methylhistidine; lowered urinary C-peptide; no change in indirectly or directly measured thermal energy losses; and a blood level related rise in breath and urinary ethanol losses. All of these changes promptly reversed during the middle (week 3 in 5-week experiment) and final control weeks. Accounting for all diet-related energy losses (urine, breath, thermal), the fuel value of the ethanol-containing diet relative to the glucose control formula varied between 0.95 and 0.99, depending upon the blood alcohol level. Hence weight loss during short-term (seven-day) ethanol infusion is unrelated to overall negative energy balance, stems primarily from decrements in protein, minerals, and fluid, and may in part be mediated by the reduction in insulin secretion that accompanies switching from dietary glucose to ethanol.
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U2 - 10.1016/0026-0495(89)90251-5
DO - 10.1016/0026-0495(89)90251-5
M3 - Article
C2 - 2913463
AN - SCOPUS:0024494719
SN - 0026-0495
VL - 38
SP - 125
EP - 135
JO - Metabolism
JF - Metabolism
IS - 2
ER -