Ethanol potentiation of central nervous system trauma

Eugene S. Flamm, H. B. Demopoulos, M. L. Seligman, J. J. Tomasula, V. De Crescito, J. Ransohoff

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Two models have been used to study the effects of ethanol on injuries of the central nervous system. The spinal cords of cats were injured by delivering a 200 gm cm impact to the exposed dura mater. A second group of animals received a similar injury to the exposed dura mater overlying the cerebral hemispheres. The animals were divided into two groups, those that received an infusion of ethanol before injury, and control animals that received no ethanol. The injuries produced were small and insignificant lesions in the animals which had received no ethanol; however, when the animals were pretreated with ethanol, a considerable increase in the extent of the injury was noted. The mechanisms by which this potentiation is produced are briefly discussed. These include alterations in membrane bound enzymes and clotting mechanisms, and alteration of cell membranes through abnormal free radical reactions.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalJournal of Neurosurgery
Volume46
Issue number3
StatePublished - 1977
Externally publishedYes

Fingerprint

Nervous System Trauma
Ethanol
Central Nervous System
Wounds and Injuries
Dura Mater
Cerebrum
Free Radicals
Spinal Cord
Cats
Cell Membrane
Membranes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Flamm, E. S., Demopoulos, H. B., Seligman, M. L., Tomasula, J. J., De Crescito, V., & Ransohoff, J. (1977). Ethanol potentiation of central nervous system trauma. Journal of Neurosurgery, 46(3), 328-335.

Ethanol potentiation of central nervous system trauma. / Flamm, Eugene S.; Demopoulos, H. B.; Seligman, M. L.; Tomasula, J. J.; De Crescito, V.; Ransohoff, J.

In: Journal of Neurosurgery, Vol. 46, No. 3, 1977, p. 328-335.

Research output: Contribution to journalArticle

Flamm, ES, Demopoulos, HB, Seligman, ML, Tomasula, JJ, De Crescito, V & Ransohoff, J 1977, 'Ethanol potentiation of central nervous system trauma', Journal of Neurosurgery, vol. 46, no. 3, pp. 328-335.
Flamm ES, Demopoulos HB, Seligman ML, Tomasula JJ, De Crescito V, Ransohoff J. Ethanol potentiation of central nervous system trauma. Journal of Neurosurgery. 1977;46(3):328-335.
Flamm, Eugene S. ; Demopoulos, H. B. ; Seligman, M. L. ; Tomasula, J. J. ; De Crescito, V. ; Ransohoff, J. / Ethanol potentiation of central nervous system trauma. In: Journal of Neurosurgery. 1977 ; Vol. 46, No. 3. pp. 328-335.
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