Etanercept-induced myositis: Do We have to stop it? a surprising outcome

Hassan Tariq, Bibi Ayesha, Karen M. Weidenheim, Giovanni Franchin

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Abstract

We discuss a case of a 47-year-old man who presented with progressive proximal muscle weakness of the upper and lower extremities and unstable gait. He had been on etanercept for 6 months for severe psoriasis and psoriatic arthritis with good control of his disease. Serum creatine kinase (CK) level was found to be 5666 U/L and muscle biopsy showed a marked inflammatory myopathic process likely secondary to etanercept. He was started on high-dose steroids and advised to discontinue etanercept. Despite our recommendation, he never stopped using etanercept due to fear of a psoriasis flare. Three months later, he had significant improvement of clinical symptoms, normalised serum CK levels and discontinued prednisone.

Original languageEnglish (US)
Article number213577
JournalBMJ Case Reports
Volume2016
DOIs
Publication statusPublished - Jan 11 2016

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ASJC Scopus subject areas

  • Medicine(all)

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