Estimation of myocardial water content using transverse relaxation time from dual spin-echo magnetic resonance imaging

Lawrence M. Boxt, Daphne T. Hsu, Jose Katz, Paul Detweiler, Stuart Mclaughlin, Thomas J. Kolb, Henry M. Spotnitz

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Dual spin-echo magnetic resonance imaging may be used for calculation of transverse myocardial relaxation time from the signal intensity of the echoes considered. In this study, the ability of myocardial transverse relaxation time (T2) to quantitate myocardial edema of the right ventricle (RV) and left ventricle (LV) was tested. Dual spin-echo magnetic resonance images of the entire hearts were obtained and T2 of the RV and LV myocardium calculated from the signal intensities within multiple regions of interest distributed over the myocardium. Six hearts were intermittently perfused through an aortic cannula with three perfusates of decreasing osmolality. Biopsies were obtained for water content (WC) analysis both before and after imaging the hearts at baseline and post-perfusion. A seventh (control) heart was not perfused; instead dual spin-echo imaging was performed at the same time intervals as in the perfused hearts. Prior to any intervention, there was no significant difference between baseline RV (79.49 ± 2.10%) and LV (77.99 ± 2.44%, p = .2) myocardial water content; RV myocardial T2 (59.9 ± 5.8 msec) was slightly but not significantly longer than that of the LV (54.6 ± 5.7 msec, p = .1). After induction of edema, strong correlation was found between right ventricular myocardial water content measurements and right ventricular T2 (RV WC = 68.5 + 0.19 × RV T2; N = 27, R = 0.92, p < .0001, SEE = 1.56%). Similarly, strong correlation was found between left ventricular myocardial water content and T2 (LV WC = 62.1 + 0.29 × LV T2; N = 27, R = 0.92, p < .0001, SEE = 1.80%). However, slopes of these two regression lines were significantly different (p < .01). Thus, we conclude that myocardial T2 may be used to quantitate regional myocardial edema. Differences in the relationship between RV and LV myocardial water content and their effect on T2 may represent differences in the manner each tissue distributes edema fluid.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalMagnetic Resonance Imaging
Volume11
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Magnetic resonance
Relaxation time
Water content
moisture content
Heart Ventricles
magnetic resonance
echoes
relaxation time
edema
Magnetic Resonance Imaging
Imaging techniques
Water
programming environments
myocardium
Edema
cannulae
Biopsy
regression analysis
Myocardium
induction

Keywords

  • MRI
  • Myocardial edema
  • Transverse relaxation

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Estimation of myocardial water content using transverse relaxation time from dual spin-echo magnetic resonance imaging. / Boxt, Lawrence M.; Hsu, Daphne T.; Katz, Jose; Detweiler, Paul; Mclaughlin, Stuart; Kolb, Thomas J.; Spotnitz, Henry M.

In: Magnetic Resonance Imaging, Vol. 11, No. 3, 1993, p. 375-383.

Research output: Contribution to journalArticle

Boxt, Lawrence M. ; Hsu, Daphne T. ; Katz, Jose ; Detweiler, Paul ; Mclaughlin, Stuart ; Kolb, Thomas J. ; Spotnitz, Henry M. / Estimation of myocardial water content using transverse relaxation time from dual spin-echo magnetic resonance imaging. In: Magnetic Resonance Imaging. 1993 ; Vol. 11, No. 3. pp. 375-383.
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abstract = "Dual spin-echo magnetic resonance imaging may be used for calculation of transverse myocardial relaxation time from the signal intensity of the echoes considered. In this study, the ability of myocardial transverse relaxation time (T2) to quantitate myocardial edema of the right ventricle (RV) and left ventricle (LV) was tested. Dual spin-echo magnetic resonance images of the entire hearts were obtained and T2 of the RV and LV myocardium calculated from the signal intensities within multiple regions of interest distributed over the myocardium. Six hearts were intermittently perfused through an aortic cannula with three perfusates of decreasing osmolality. Biopsies were obtained for water content (WC) analysis both before and after imaging the hearts at baseline and post-perfusion. A seventh (control) heart was not perfused; instead dual spin-echo imaging was performed at the same time intervals as in the perfused hearts. Prior to any intervention, there was no significant difference between baseline RV (79.49 ± 2.10{\%}) and LV (77.99 ± 2.44{\%}, p = .2) myocardial water content; RV myocardial T2 (59.9 ± 5.8 msec) was slightly but not significantly longer than that of the LV (54.6 ± 5.7 msec, p = .1). After induction of edema, strong correlation was found between right ventricular myocardial water content measurements and right ventricular T2 (RV WC = 68.5 + 0.19 × RV T2; N = 27, R = 0.92, p < .0001, SEE = 1.56{\%}). Similarly, strong correlation was found between left ventricular myocardial water content and T2 (LV WC = 62.1 + 0.29 × LV T2; N = 27, R = 0.92, p < .0001, SEE = 1.80{\%}). However, slopes of these two regression lines were significantly different (p < .01). Thus, we conclude that myocardial T2 may be used to quantitate regional myocardial edema. Differences in the relationship between RV and LV myocardial water content and their effect on T2 may represent differences in the manner each tissue distributes edema fluid.",
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AB - Dual spin-echo magnetic resonance imaging may be used for calculation of transverse myocardial relaxation time from the signal intensity of the echoes considered. In this study, the ability of myocardial transverse relaxation time (T2) to quantitate myocardial edema of the right ventricle (RV) and left ventricle (LV) was tested. Dual spin-echo magnetic resonance images of the entire hearts were obtained and T2 of the RV and LV myocardium calculated from the signal intensities within multiple regions of interest distributed over the myocardium. Six hearts were intermittently perfused through an aortic cannula with three perfusates of decreasing osmolality. Biopsies were obtained for water content (WC) analysis both before and after imaging the hearts at baseline and post-perfusion. A seventh (control) heart was not perfused; instead dual spin-echo imaging was performed at the same time intervals as in the perfused hearts. Prior to any intervention, there was no significant difference between baseline RV (79.49 ± 2.10%) and LV (77.99 ± 2.44%, p = .2) myocardial water content; RV myocardial T2 (59.9 ± 5.8 msec) was slightly but not significantly longer than that of the LV (54.6 ± 5.7 msec, p = .1). After induction of edema, strong correlation was found between right ventricular myocardial water content measurements and right ventricular T2 (RV WC = 68.5 + 0.19 × RV T2; N = 27, R = 0.92, p < .0001, SEE = 1.56%). Similarly, strong correlation was found between left ventricular myocardial water content and T2 (LV WC = 62.1 + 0.29 × LV T2; N = 27, R = 0.92, p < .0001, SEE = 1.80%). However, slopes of these two regression lines were significantly different (p < .01). Thus, we conclude that myocardial T2 may be used to quantitate regional myocardial edema. Differences in the relationship between RV and LV myocardial water content and their effect on T2 may represent differences in the manner each tissue distributes edema fluid.

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