Esthesioneuroblastoma

Thomas J. Ow, Diana Bell, Michael E. Kupferman, Franco DeMonte, Ehab Y. Hanna

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Esthesioneuroblastoma is a rare malignant neoplasm in the olfactory region of the nasal cavity and anterior skull base. Diagnosis and staging require anatomic imaging and careful pathologic assessment. Standard treatment is anterior craniofacial resection with postoperative irradiation. The role for chemotherapy is not defined, but is generally for the most advanced cases and used in the neoadjuvant setting and/or postoperatively with irradiation. Prognosis is favorable; however, metastasis rates remain relatively high. Regional and distant metastasis portends a poor outcome. Intensity-modulated radiation treatment and endoscopic surgery have reduced morbidity, but outcomes with these techniques must be fully evaluated.

Original languageEnglish (US)
Pages (from-to)51-65
Number of pages15
JournalNeurosurgery Clinics of North America
Volume24
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Olfactory Esthesioneuroblastoma
Neoplasm Metastasis
Nasal Cavity
Skull Base
Radiation
Morbidity
Drug Therapy
Therapeutics
Neoplasms

Keywords

  • Endoscopic resection
  • Esthesioneuroblastoma
  • Multimodality treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Ow, T. J., Bell, D., Kupferman, M. E., DeMonte, F., & Hanna, E. Y. (2013). Esthesioneuroblastoma. Neurosurgery Clinics of North America, 24(1), 51-65. https://doi.org/10.1016/j.nec.2012.08.005

Esthesioneuroblastoma. / Ow, Thomas J.; Bell, Diana; Kupferman, Michael E.; DeMonte, Franco; Hanna, Ehab Y.

In: Neurosurgery Clinics of North America, Vol. 24, No. 1, 01.2013, p. 51-65.

Research output: Contribution to journalArticle

Ow, TJ, Bell, D, Kupferman, ME, DeMonte, F & Hanna, EY 2013, 'Esthesioneuroblastoma', Neurosurgery Clinics of North America, vol. 24, no. 1, pp. 51-65. https://doi.org/10.1016/j.nec.2012.08.005
Ow TJ, Bell D, Kupferman ME, DeMonte F, Hanna EY. Esthesioneuroblastoma. Neurosurgery Clinics of North America. 2013 Jan;24(1):51-65. https://doi.org/10.1016/j.nec.2012.08.005
Ow, Thomas J. ; Bell, Diana ; Kupferman, Michael E. ; DeMonte, Franco ; Hanna, Ehab Y. / Esthesioneuroblastoma. In: Neurosurgery Clinics of North America. 2013 ; Vol. 24, No. 1. pp. 51-65.
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