Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

Swarna Mehrotra; Bhumika Sharma; Sonali Joshi; Barbara Kroczynska; Beata Majchrzak; Brady L. Stein; Brandon McMahon; Jessica K. Altman; Jonathan D. Licht; Darren P. Baker; Elizabeth A. Eklund; Amittha Wickrema; Amit Verma; Eleanor N. Fish; Leonidas C. Platanias

doi:10.1074/jbc.M113.476192

Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

Swarna Mehrotra, Bhumika Sharma, Sonali Joshi, Barbara Kroczynska, Beata Majchrzak, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Jonathan D. Licht, Darren P. Baker, Elizabeth A. Eklund, Amittha Wickrema, Amit Verma, Eleanor N. Fish, Leonidas C. Platanias

Oncology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.

Original language	English (US)
Pages (from-to)	23814-23822
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.476192
State	Published - Aug 16 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Mehrotra, S., Sharma, B., Joshi, S., Kroczynska, B., Majchrzak, B., Stein, B. L., McMahon, B., Altman, J. K., Licht, J. D., Baker, D. P., Eklund, E. A., Wickrema, A., Verma, A., Fish, E. N., & Platanias, L. C. (2013). Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors. Journal of Biological Chemistry, 288(33), 23814-23822. https://doi.org/10.1074/jbc.M113.476192

Mehrotra, S, Sharma, B, Joshi, S, Kroczynska, B, Majchrzak, B, Stein, BL, McMahon, B, Altman, JK, Licht, JD, Baker, DP, Eklund, EA, Wickrema, A, Verma, A, Fish, EN & Platanias, LC 2013, 'Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors', Journal of Biological Chemistry, vol. 288, no. 33, pp. 23814-23822. https://doi.org/10.1074/jbc.M113.476192

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title = "Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors",

abstract = "Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.",

author = "Swarna Mehrotra and Bhumika Sharma and Sonali Joshi and Barbara Kroczynska and Beata Majchrzak and Stein, {Brady L.} and Brandon McMahon and Altman, {Jessica K.} and Licht, {Jonathan D.} and Baker, {Darren P.} and Eklund, {Elizabeth A.} and Amittha Wickrema and Amit Verma and Fish, {Eleanor N.} and Platanias, {Leonidas C.}",

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doi = "10.1074/jbc.M113.476192",

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AU - Sharma, Bhumika

AU - Joshi, Sonali

AU - Kroczynska, Barbara

AU - Majchrzak, Beata

AU - Stein, Brady L.

AU - McMahon, Brandon

AU - Altman, Jessica K.

AU - Licht, Jonathan D.

AU - Baker, Darren P.

AU - Eklund, Elizabeth A.

AU - Wickrema, Amittha

AU - Verma, Amit

AU - Fish, Eleanor N.

AU - Platanias, Leonidas C.

PY - 2013/8/16

Y1 - 2013/8/16

N2 - Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.

AB - Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.

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Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

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