Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

Swarna Mehrotra, Bhumika Sharma, Sonali Joshi, Barbara Kroczynska, Beata Majchrzak, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Jonathan D. Licht, Darren P. Baker, Elizabeth A. Eklund, Amittha Wickrema, Amit Verma, Eleanor N. Fish, Leonidas C. Platanias

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.

Original languageEnglish (US)
Pages (from-to)23814-23822
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Mehrotra, S., Sharma, B., Joshi, S., Kroczynska, B., Majchrzak, B., Stein, B. L., McMahon, B., Altman, J. K., Licht, J. D., Baker, D. P., Eklund, E. A., Wickrema, A., Verma, A., Fish, E. N., & Platanias, L. C. (2013). Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors. Journal of Biological Chemistry, 288(33), 23814-23822. https://doi.org/10.1074/jbc.M113.476192