Essential role for Max in early embryonic growth and development

Hong Shen-Li, Rónán C. O'Hagan, Harry Hou, James W. Horner, Han Woong Lee, Ronald A. DePinho

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Loss of Max function in the mouse resulted in generalized developmental arrest of both embryonic and extra-embryonic tissues at early postimplantation (~E5.5-6.5), coincident with loss or dilution of maternal Max stores in the expanding embryo in vivo and in blastocyst outgrowths in vitro. Developmentally arrested embryos were reduced in size and exhibited widespread cytological degeneration and feeble BrdU incorporation. Max and, by extension, the Myc superfamily, serve essential roles in early mammalian development and a maternal reservoir of Max exists in sufficient amount to sustain Myc superfamily function through preimplantation stages of development.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalGenes and Development
Volume14
Issue number1
Publication statusPublished - Jan 1 2000

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Keywords

  • Mammalian development
  • Max
  • Myc function

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Shen-Li, H., O'Hagan, R. C., Hou, H., Horner, J. W., Lee, H. W., & DePinho, R. A. (2000). Essential role for Max in early embryonic growth and development. Genes and Development, 14(1), 17-22.