Esophagitis, treatment-related toxicity in non-small cell lung cancer

Voichita Bar-Ad, Nitin Ohri, Maria Werner-Wasik

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objectives: Radiation esophagitis represents a significant complication experienced by non-small cell cancer (NSCLC) patients receiving thoracic irradiation. The objective of the current review was to assess the clinical and dosimetrical parameters that may predict radiation esophagitis. Methods: Studies were identified by searching PubMed electronic databases. Both prospective and retrospective studies were included. Information regarding clinical and dosimetrical parameters predicting for radiation-induced esophagitis was extracted and analyzed. Results: The esophageal clinical and dosimetric parameters that best predict acute esophagitis remain unclear. In many reports, Vx (the volume of esophagus receiving x Gy) stands out, with values of x ranging from 20-70 Gy. Other studies conclude that the maximal dose received by any point of the esophagus is the best predictor of esophagitis. Another metric implicated with esophageal toxicity in some reports is the proportion of the esophageal circumference or surface area that receives high doses of radiation. Conclusions: Technological advancements in patient immobilization, setup verification, and radiotherapy delivery are increasingly being employed to limit the toxicity of thoracic irradiation. Future efforts are required to determine how these complex techniques should best be implemented to minimize the risks of acute and long-term esophageal injury.

Original languageEnglish (US)
Pages (from-to)31-35
Number of pages5
JournalReviews on Recent Clinical Trials
Volume7
Issue number1
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Esophagitis
Non-Small Cell Lung Carcinoma
Radiation
Esophagus
Thorax
Therapeutics
PubMed
Immobilization
Radiotherapy
Retrospective Studies
Databases
Prospective Studies
Wounds and Injuries
Neoplasms

Keywords

  • Esophagitis
  • Non-Small Cell Lung Cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology

Cite this

Esophagitis, treatment-related toxicity in non-small cell lung cancer. / Bar-Ad, Voichita; Ohri, Nitin; Werner-Wasik, Maria.

In: Reviews on Recent Clinical Trials, Vol. 7, No. 1, 02.2012, p. 31-35.

Research output: Contribution to journalArticle

Bar-Ad, Voichita ; Ohri, Nitin ; Werner-Wasik, Maria. / Esophagitis, treatment-related toxicity in non-small cell lung cancer. In: Reviews on Recent Clinical Trials. 2012 ; Vol. 7, No. 1. pp. 31-35.
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