Esophageal capsule endoscopy after radiofrequency catheter ablation for atrial fibrillation: Documented higher risk of luminal esophageal damage with general anesthesia as compared with conscious sedation

Luigi Di Biase, Luis Carlos Saenz, David J. Burkhardt, Miguel Vacca, Claude S. Elayi, Conor D. Barrett, Rodney Horton, Rong Bai, Alan Siu, Tamer S. Fahmy, Dimpi Patel, Luciana Armaganijan, Chia Tung Wu, Sonne Kai, Ching Keong Ching, Karen Phillips, Robert A. Schweikert, Jennifer E. Cummings, Mauricio Arruda, Walid I. SalibaMilan Dodig, Andrea Natale

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Background-Left atrioesophageal fistula is a rare but devastating complication that may occur after catheter ablation of atrial fibrillation. We used capsule endoscopy to assess esophageal injury after catheter ablation for atrial fibrillation in a population randomized to undergo general anesthesia or conscious sedation. Methods and Results-Fifty patients undergoing atrial fibrillation ablation for paroxysmal symptomatic atrial fibrillation refractory to antiarrhythmic drugs were enrolled and randomized, including those undergoing the procedure under general anesthesia (25 patients, group 1) and those receiving conscious sedation with fentanyl or midazolam (25 patients, group 2). All patients underwent esophageal temperature monitoring during the procedure. The day after ablation, all patients had capsule endoscopy to assess the presence of endoluminal tissue damage of the esophagus. We observed esophageal tissue damage in 12 (48%) patients of group 1 and 1 esophageal tissue damage in a single patient (4%) of group 2 (P<0.001). The maximal esophageal temperature was significantly higher in patients undergoing general anesthesia (group 1) versus patients undergoing conscious sedation (group 2) (40.6±1°C versus 39.6±0.8°C; P< 0.003). The time to peak temperature was 9±7 seconds in group 1 and 21±9 seconds in group 2, and this difference was statistically significant (P<0.001). No complication occurred during or after the administration of the pill cam or during the procedures. All esophageal lesions normalized at the 2-month repeat endoscopic examination. Conclusion-The use of general anesthesia increases the risk of esophageal damage detected by capsule endoscopy. (Circ Arrhythmia Electrophysiol. 2009;2:108-112.)

Original languageEnglish (US)
Pages (from-to)108-112
Number of pages5
JournalCirculation: Arrhythmia and Electrophysiology
Volume2
Issue number2
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Conscious Sedation
Capsule Endoscopy
Catheter Ablation
General Anesthesia
Atrial Fibrillation
Temperature
Anti-Arrhythmia Agents
Midazolam
Fentanyl
Esophagus
Fistula
Cardiac Arrhythmias

Keywords

  • Catheter ablation of atrial fibrillation
  • Complications
  • Esophageal injury
  • Left atrioesophageal fistula
  • Left atrium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Esophageal capsule endoscopy after radiofrequency catheter ablation for atrial fibrillation : Documented higher risk of luminal esophageal damage with general anesthesia as compared with conscious sedation. / Di Biase, Luigi; Saenz, Luis Carlos; Burkhardt, David J.; Vacca, Miguel; Elayi, Claude S.; Barrett, Conor D.; Horton, Rodney; Bai, Rong; Siu, Alan; Fahmy, Tamer S.; Patel, Dimpi; Armaganijan, Luciana; Wu, Chia Tung; Kai, Sonne; Ching, Ching Keong; Phillips, Karen; Schweikert, Robert A.; Cummings, Jennifer E.; Arruda, Mauricio; Saliba, Walid I.; Dodig, Milan; Natale, Andrea.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 2, No. 2, 04.2009, p. 108-112.

Research output: Contribution to journalArticle

Di Biase, L, Saenz, LC, Burkhardt, DJ, Vacca, M, Elayi, CS, Barrett, CD, Horton, R, Bai, R, Siu, A, Fahmy, TS, Patel, D, Armaganijan, L, Wu, CT, Kai, S, Ching, CK, Phillips, K, Schweikert, RA, Cummings, JE, Arruda, M, Saliba, WI, Dodig, M & Natale, A 2009, 'Esophageal capsule endoscopy after radiofrequency catheter ablation for atrial fibrillation: Documented higher risk of luminal esophageal damage with general anesthesia as compared with conscious sedation', Circulation: Arrhythmia and Electrophysiology, vol. 2, no. 2, pp. 108-112. https://doi.org/10.1161/CIRCEP.108.815266
Di Biase, Luigi ; Saenz, Luis Carlos ; Burkhardt, David J. ; Vacca, Miguel ; Elayi, Claude S. ; Barrett, Conor D. ; Horton, Rodney ; Bai, Rong ; Siu, Alan ; Fahmy, Tamer S. ; Patel, Dimpi ; Armaganijan, Luciana ; Wu, Chia Tung ; Kai, Sonne ; Ching, Ching Keong ; Phillips, Karen ; Schweikert, Robert A. ; Cummings, Jennifer E. ; Arruda, Mauricio ; Saliba, Walid I. ; Dodig, Milan ; Natale, Andrea. / Esophageal capsule endoscopy after radiofrequency catheter ablation for atrial fibrillation : Documented higher risk of luminal esophageal damage with general anesthesia as compared with conscious sedation. In: Circulation: Arrhythmia and Electrophysiology. 2009 ; Vol. 2, No. 2. pp. 108-112.
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T2 - Documented higher risk of luminal esophageal damage with general anesthesia as compared with conscious sedation

AU - Di Biase, Luigi

AU - Saenz, Luis Carlos

AU - Burkhardt, David J.

AU - Vacca, Miguel

AU - Elayi, Claude S.

AU - Barrett, Conor D.

AU - Horton, Rodney

AU - Bai, Rong

AU - Siu, Alan

AU - Fahmy, Tamer S.

AU - Patel, Dimpi

AU - Armaganijan, Luciana

AU - Wu, Chia Tung

AU - Kai, Sonne

AU - Ching, Ching Keong

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AU - Schweikert, Robert A.

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AU - Arruda, Mauricio

AU - Saliba, Walid I.

AU - Dodig, Milan

AU - Natale, Andrea

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N2 - Background-Left atrioesophageal fistula is a rare but devastating complication that may occur after catheter ablation of atrial fibrillation. We used capsule endoscopy to assess esophageal injury after catheter ablation for atrial fibrillation in a population randomized to undergo general anesthesia or conscious sedation. Methods and Results-Fifty patients undergoing atrial fibrillation ablation for paroxysmal symptomatic atrial fibrillation refractory to antiarrhythmic drugs were enrolled and randomized, including those undergoing the procedure under general anesthesia (25 patients, group 1) and those receiving conscious sedation with fentanyl or midazolam (25 patients, group 2). All patients underwent esophageal temperature monitoring during the procedure. The day after ablation, all patients had capsule endoscopy to assess the presence of endoluminal tissue damage of the esophagus. We observed esophageal tissue damage in 12 (48%) patients of group 1 and 1 esophageal tissue damage in a single patient (4%) of group 2 (P<0.001). The maximal esophageal temperature was significantly higher in patients undergoing general anesthesia (group 1) versus patients undergoing conscious sedation (group 2) (40.6±1°C versus 39.6±0.8°C; P< 0.003). The time to peak temperature was 9±7 seconds in group 1 and 21±9 seconds in group 2, and this difference was statistically significant (P<0.001). No complication occurred during or after the administration of the pill cam or during the procedures. All esophageal lesions normalized at the 2-month repeat endoscopic examination. Conclusion-The use of general anesthesia increases the risk of esophageal damage detected by capsule endoscopy. (Circ Arrhythmia Electrophysiol. 2009;2:108-112.)

AB - Background-Left atrioesophageal fistula is a rare but devastating complication that may occur after catheter ablation of atrial fibrillation. We used capsule endoscopy to assess esophageal injury after catheter ablation for atrial fibrillation in a population randomized to undergo general anesthesia or conscious sedation. Methods and Results-Fifty patients undergoing atrial fibrillation ablation for paroxysmal symptomatic atrial fibrillation refractory to antiarrhythmic drugs were enrolled and randomized, including those undergoing the procedure under general anesthesia (25 patients, group 1) and those receiving conscious sedation with fentanyl or midazolam (25 patients, group 2). All patients underwent esophageal temperature monitoring during the procedure. The day after ablation, all patients had capsule endoscopy to assess the presence of endoluminal tissue damage of the esophagus. We observed esophageal tissue damage in 12 (48%) patients of group 1 and 1 esophageal tissue damage in a single patient (4%) of group 2 (P<0.001). The maximal esophageal temperature was significantly higher in patients undergoing general anesthesia (group 1) versus patients undergoing conscious sedation (group 2) (40.6±1°C versus 39.6±0.8°C; P< 0.003). The time to peak temperature was 9±7 seconds in group 1 and 21±9 seconds in group 2, and this difference was statistically significant (P<0.001). No complication occurred during or after the administration of the pill cam or during the procedures. All esophageal lesions normalized at the 2-month repeat endoscopic examination. Conclusion-The use of general anesthesia increases the risk of esophageal damage detected by capsule endoscopy. (Circ Arrhythmia Electrophysiol. 2009;2:108-112.)

KW - Catheter ablation of atrial fibrillation

KW - Complications

KW - Esophageal injury

KW - Left atrioesophageal fistula

KW - Left atrium

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