Erythema chronicum migrans and Lyme arthritis

Cryoimmunoglobulins and clinical activity of skin and joints

Allen C. Steere, John A. Hardin, Stephen E. Malawista

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We report the presence of serum cryoimmunoglobulins in patients with attacks of a newly described epidemic arthritis-Lyme arthritis-and in some patients with a characteristic skin lesion-erythema chronicum migrans-that sometimes precedes the onset of the arthritis. Seven patients who had cryoimmunoglobulins at the time of the skin lesion have developed arthritis; four patients without them have not. The cryoglobulins in patients with the skin lesion consisted primarily of immunoglobulin M (IgM); those in patients with arthritis often included both IgM and IgG. These findings support the hypothesis that a common origin exists for the skin and joint lesions and suggest that circulating immune complexes may have a pathogenetic role in Lyme arthritis.

Original languageEnglish (US)
Pages (from-to)1121-1122
Number of pages2
JournalScience
Volume196
Issue number4294
StatePublished - 1977
Externally publishedYes

Fingerprint

Erythema Chronicum Migrans
Lyme Disease
Joints
Skin
Arthritis
Immunoglobulin M
Cryoglobulins
Antigen-Antibody Complex
Immunoglobulin G
Serum

ASJC Scopus subject areas

  • General

Cite this

Steere, A. C., Hardin, J. A., & Malawista, S. E. (1977). Erythema chronicum migrans and Lyme arthritis: Cryoimmunoglobulins and clinical activity of skin and joints. Science, 196(4294), 1121-1122.

Erythema chronicum migrans and Lyme arthritis : Cryoimmunoglobulins and clinical activity of skin and joints. / Steere, Allen C.; Hardin, John A.; Malawista, Stephen E.

In: Science, Vol. 196, No. 4294, 1977, p. 1121-1122.

Research output: Contribution to journalArticle

Steere, AC, Hardin, JA & Malawista, SE 1977, 'Erythema chronicum migrans and Lyme arthritis: Cryoimmunoglobulins and clinical activity of skin and joints', Science, vol. 196, no. 4294, pp. 1121-1122.
Steere, Allen C. ; Hardin, John A. ; Malawista, Stephen E. / Erythema chronicum migrans and Lyme arthritis : Cryoimmunoglobulins and clinical activity of skin and joints. In: Science. 1977 ; Vol. 196, No. 4294. pp. 1121-1122.
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