ERK2 contributes to the control of social behaviors in mice

Yasushi Satoh, Shogo Endo, Takahiro Nakata, Yasushi Kobayashi, Kazuyuki Yamada, Toshio Ikeda, Atsuya Takeuchi, Takeshi Hiramoto, Yasuhiro Watanabe, Tomiei Kazama

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Signaling through extracellular signal-regulated kinase (ERK) is important in multiple signal transduction networks in the CNS. However, the specific role of ERK2 in in vivo brain functions is not fully understood. Here we show that ERK2 play a critical role in regulating social behaviors as well as cognitive and emotional behaviors in mice. To study the brain function of ERK2, we used a conditional, region-specific, genetic approach to target Erk2 using the Cre/loxP strategy with a nestin promoter-driven cre transgenic mouse line to induce recombination in the CNS. The resulting Erk2 conditional knock-out (CKO) mice, in which Erk2 was abrogated specifically in the CNS, were viable and fertile with a normal appearance. These mice, however, exhibited marked anomalies in multiple aspects of social behaviors related to facets of autism-spectrum disorders: elevated aggressive behaviors, deficits in maternal nurturing, poor nestbuilding, and lower levels of social familiarity and social interaction. Erk2 CKO mice also exhibited decreased anxiety-related behaviors and impaired long-term memory. Pharmacological inhibition of ERK1 phosphorylation in Erk2CKOmice did not affect the impairments in social behaviors and learning disabilities, indicating that ERK2, but not ERK1 plays a critical role in these behaviors. Our findings suggest thatERK2has complex and multiple roles in the CNS, with important implications forhumanpsychiatric disorders characterized by deficits in social behaviors.

Original languageEnglish (US)
Pages (from-to)11953-11967
Number of pages15
JournalJournal of Neuroscience
Volume31
Issue number33
DOIs
StatePublished - Aug 17 2011
Externally publishedYes

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Social Behavior
Knockout Mice
Nestin
Long-Term Memory
Learning Disorders
Extracellular Signal-Regulated MAP Kinases
Brain
Interpersonal Relations
Transgenic Mice
Genetic Recombination
Signal Transduction
Anxiety
Phosphorylation
Mothers
Pharmacology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., ... Kazama, T. (2011). ERK2 contributes to the control of social behaviors in mice. Journal of Neuroscience, 31(33), 11953-11967. https://doi.org/10.1523/JNEUROSCI.2349-11.2011

ERK2 contributes to the control of social behaviors in mice. / Satoh, Yasushi; Endo, Shogo; Nakata, Takahiro; Kobayashi, Yasushi; Yamada, Kazuyuki; Ikeda, Toshio; Takeuchi, Atsuya; Hiramoto, Takeshi; Watanabe, Yasuhiro; Kazama, Tomiei.

In: Journal of Neuroscience, Vol. 31, No. 33, 17.08.2011, p. 11953-11967.

Research output: Contribution to journalArticle

Satoh, Y, Endo, S, Nakata, T, Kobayashi, Y, Yamada, K, Ikeda, T, Takeuchi, A, Hiramoto, T, Watanabe, Y & Kazama, T 2011, 'ERK2 contributes to the control of social behaviors in mice', Journal of Neuroscience, vol. 31, no. 33, pp. 11953-11967. https://doi.org/10.1523/JNEUROSCI.2349-11.2011
Satoh Y, Endo S, Nakata T, Kobayashi Y, Yamada K, Ikeda T et al. ERK2 contributes to the control of social behaviors in mice. Journal of Neuroscience. 2011 Aug 17;31(33):11953-11967. https://doi.org/10.1523/JNEUROSCI.2349-11.2011
Satoh, Yasushi ; Endo, Shogo ; Nakata, Takahiro ; Kobayashi, Yasushi ; Yamada, Kazuyuki ; Ikeda, Toshio ; Takeuchi, Atsuya ; Hiramoto, Takeshi ; Watanabe, Yasuhiro ; Kazama, Tomiei. / ERK2 contributes to the control of social behaviors in mice. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 33. pp. 11953-11967.
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