Eradicating the mediators of neuronal death with a fine-tooth comb

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ischemic tolerance is an evolutionarily conserved form of cerebral plasticity in which a brief period of cerebral ischemia (called ischemic preconditioning) confers transient tolerance to a subsequent ischemic challenge in the brain. Polycomb group proteins are gene-silencing factors that are abundant and widely distributed during embryogenesis and are essential to epigenetic cellular memory, pluripotency, and stem cell self-renewal. New insight into the molecular mechanisms underlying ischemic tolerance is highlighted by the finding that ischemic preconditioning activates polycomb proteins in mature neurons. Polycomb proteins act through epigenetic gene silencing to eradicate potential mediators of neuronal death and promote cellular arrest, enabling mature neurons to survive ischemic stroke.

Original languageEnglish (US)
JournalScience Signaling
Volume3
Issue number125
DOIs
StatePublished - Jun 8 2010
Externally publishedYes

Fingerprint

Comb and Wattles
Ischemic Preconditioning
Gene Silencing
Epigenomics
Tooth
Polycomb-Group Proteins
Neurons
Genes
Brain Ischemia
Embryonic Development
Proteins
Stroke
Stem cells
Plasticity
Brain
Data storage equipment
Cell Self Renewal

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Eradicating the mediators of neuronal death with a fine-tooth comb. / Zukin, R. Suzanne.

In: Science Signaling, Vol. 3, No. 125, 08.06.2010.

Research output: Contribution to journalArticle

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