Epstein-Barr virus specific antibodies in patients with coeliac disease

Shinji Harada; John Greally; Jack Davis; Nancy Synder; Fiona Stevens; Claran McCarthy; David T. Purtilo

doi:10.1007/BF02937215

Epstein-Barr virus specific antibodies in patients with coeliac disease

Shinji Harada, John Greally, Jack Davis, Nancy Synder, Fiona Stevens, Claran McCarthy, David T. Purtilo

Research output: Contribution to journal › Article › peer-review

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Abstract

SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.

Original language	English (US)
Pages (from-to)	416-421
Number of pages	6
Journal	Irish Journal of Medical Science
Volume	154
Issue number	11
DOIs	https://doi.org/10.1007/BF02937215
State	Published - Nov 1985
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1007/BF02937215

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title = "Epstein-Barr virus specific antibodies in patients with coeliac disease",

abstract = "SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.",

author = "Shinji Harada and John Greally and Jack Davis and Nancy Synder and Fiona Stevens and Claran McCarthy and Purtilo, {David T.}",

year = "1985",

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doi = "10.1007/BF02937215",

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T1 - Epstein-Barr virus specific antibodies in patients with coeliac disease

AU - Harada, Shinji

AU - Greally, John

AU - Davis, Jack

AU - Synder, Nancy

AU - Stevens, Fiona

AU - McCarthy, Claran

AU - Purtilo, David T.

PY - 1985/11

Y1 - 1985/11

N2 - SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.

AB - SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied. Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.

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Epstein-Barr virus specific antibodies in patients with coeliac disease

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