Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia

Stephen J. Forman, John L. Sullivan, Christine Wright, Howard Ratech, Barbara Racklin, Karl G. Blume

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The development of B cell lymphoma has been reported to occur in recipients of a variety of organ transplants, including some patients who have received an allogeneic bone marrow graft. In this report, we describe a patient with severe aplastic anemia who developed a malignant B cell lymphoplasmacytoid proliferation 48 days after undergoing allogeneic marrow transplantation from her HLA-matched MLC-nonreactive brother. Immunologic studies showed this malignancy to be a mixed polyclonal and monoclonal proliferation in donor ceils. Virologie studies documented Epstein Bare infection of the cells. A review of the literature suggests that graft-versus-host disease and treatment of this complication by antithymocyte globulin are related, to the development of the EBV-related malignancy in the 3BV-infected B cells of the developing bone marrow graft.

Original languageEnglish (US)
Pages (from-to)244-249
Number of pages6
JournalTransplantation
Volume44
Issue number2
StatePublished - 1987
Externally publishedYes

Fingerprint

Aplastic Anemia
Homologous Transplantation
Bone Marrow Transplantation
Human Herpesvirus 4
Lymphoma
Bone Marrow
Transplants
B-Lymphocytes
Antilymphocyte Serum
B-Cell Lymphoma
Graft vs Host Disease
Siblings
Neoplasms
Cell Proliferation
Tissue Donors
Infection
Therapeutics

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Forman, S. J., Sullivan, J. L., Wright, C., Ratech, H., Racklin, B., & Blume, K. G. (1987). Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia. Transplantation, 44(2), 244-249.

Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia. / Forman, Stephen J.; Sullivan, John L.; Wright, Christine; Ratech, Howard; Racklin, Barbara; Blume, Karl G.

In: Transplantation, Vol. 44, No. 2, 1987, p. 244-249.

Research output: Contribution to journalArticle

Forman, SJ, Sullivan, JL, Wright, C, Ratech, H, Racklin, B & Blume, KG 1987, 'Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia', Transplantation, vol. 44, no. 2, pp. 244-249.
Forman, Stephen J. ; Sullivan, John L. ; Wright, Christine ; Ratech, Howard ; Racklin, Barbara ; Blume, Karl G. / Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia. In: Transplantation. 1987 ; Vol. 44, No. 2. pp. 244-249.
@article{da0bd1d050ed47d8af1f7ad219ae3871,
title = "Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia",
abstract = "The development of B cell lymphoma has been reported to occur in recipients of a variety of organ transplants, including some patients who have received an allogeneic bone marrow graft. In this report, we describe a patient with severe aplastic anemia who developed a malignant B cell lymphoplasmacytoid proliferation 48 days after undergoing allogeneic marrow transplantation from her HLA-matched MLC-nonreactive brother. Immunologic studies showed this malignancy to be a mixed polyclonal and monoclonal proliferation in donor ceils. Virologie studies documented Epstein Bare infection of the cells. A review of the literature suggests that graft-versus-host disease and treatment of this complication by antithymocyte globulin are related, to the development of the EBV-related malignancy in the 3BV-infected B cells of the developing bone marrow graft.",
author = "Forman, {Stephen J.} and Sullivan, {John L.} and Christine Wright and Howard Ratech and Barbara Racklin and Blume, {Karl G.}",
year = "1987",
language = "English (US)",
volume = "44",
pages = "244--249",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia

AU - Forman, Stephen J.

AU - Sullivan, John L.

AU - Wright, Christine

AU - Ratech, Howard

AU - Racklin, Barbara

AU - Blume, Karl G.

PY - 1987

Y1 - 1987

N2 - The development of B cell lymphoma has been reported to occur in recipients of a variety of organ transplants, including some patients who have received an allogeneic bone marrow graft. In this report, we describe a patient with severe aplastic anemia who developed a malignant B cell lymphoplasmacytoid proliferation 48 days after undergoing allogeneic marrow transplantation from her HLA-matched MLC-nonreactive brother. Immunologic studies showed this malignancy to be a mixed polyclonal and monoclonal proliferation in donor ceils. Virologie studies documented Epstein Bare infection of the cells. A review of the literature suggests that graft-versus-host disease and treatment of this complication by antithymocyte globulin are related, to the development of the EBV-related malignancy in the 3BV-infected B cells of the developing bone marrow graft.

AB - The development of B cell lymphoma has been reported to occur in recipients of a variety of organ transplants, including some patients who have received an allogeneic bone marrow graft. In this report, we describe a patient with severe aplastic anemia who developed a malignant B cell lymphoplasmacytoid proliferation 48 days after undergoing allogeneic marrow transplantation from her HLA-matched MLC-nonreactive brother. Immunologic studies showed this malignancy to be a mixed polyclonal and monoclonal proliferation in donor ceils. Virologie studies documented Epstein Bare infection of the cells. A review of the literature suggests that graft-versus-host disease and treatment of this complication by antithymocyte globulin are related, to the development of the EBV-related malignancy in the 3BV-infected B cells of the developing bone marrow graft.

UR - http://www.scopus.com/inward/record.url?scp=0023635196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023635196&partnerID=8YFLogxK

M3 - Article

C2 - 2820089

AN - SCOPUS:0023635196

VL - 44

SP - 244

EP - 249

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 2

ER -