Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia

Stephen J. Forman, John L. Sullivan, Christine Wright, Howard Ratech, Barbara Racklin, Karl G. Blume

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The development of B cell lymphoma has been reported to occur in recipients of a variety of organ transplants, including some patients who have received an allogeneic bone marrow graft. In this report, we describe a patient with severe aplastic anemia who developed a malignant B cell lymphoplasmacytoid proliferation 48 days after undergoing allogeneic marrow transplantation from her HLA-matched MLC-nonreactive brother. Immunologic studies showed this malignancy to be a mixed polyclonal and monoclonal proliferation in donor ceils. Virologie studies documented Epstein Bare infection of the cells. A review of the literature suggests that graft-versus-host disease and treatment of this complication by antithymocyte globulin are related, to the development of the EBV-related malignancy in the 3BV-infected B cells of the developing bone marrow graft.

Original languageEnglish (US)
Pages (from-to)244-249
Number of pages6
JournalTransplantation
Volume44
Issue number2
StatePublished - Aug 1987

ASJC Scopus subject areas

  • Transplantation

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    Forman, S. J., Sullivan, J. L., Wright, C., Ratech, H., Racklin, B., & Blume, K. G. (1987). Epstein-barr-virus-related malignant b cell lymphoplasmacytic lymphoma following allogeneic bone marrow transplantation for aplastic anemia. Transplantation, 44(2), 244-249.