Epithelial ovarian carcinoma and fertility of parents

Susan Harlap, Sara H. Olson, John P. Curtin, Thomas A. Caputo, Christine Nakraseive, Damaris Sanchez, Xiaonan (Nan) Xue

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We studied the fertility of the parents of 163 women with epithelial ovarian carcinoma in two hospitals in New York City, compared with the parents of 159 controls from similar neighborhoods. We used unconditional logistic regression to control for covariates, including parity, oral contraceptive use, age at menarche, and Jewish ancestry. Compared with women with zero or one sibling, those with two, three or four or more siblings had adjusted odds ratios (95% confidence intervals) of 0.91 (0.47-1.77), 0.61 (0.28-1.37), and 0.50 (0.26-0.98). On average, each additional sibling was associated with a risk reduction to 0.80 (0.66-0.98). These findings support the hypothesis that heritable conditions associated with reduced fertility of the subjects' parents may contribute to risk and may explain some of the effects of parity on the risk of this carcinoma. Alternatively, they may reflect some unidentified aspect of the environment experienced by girls growing up in small families. If confirmed in other data sets, these findings imply that sibship size might have confounded previous estimates of risk associated with a family history of cancer or with Jewish ethnicity.

Original languageEnglish (US)
Pages (from-to)59-65
Number of pages7
JournalEpidemiology
Volume13
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Fertility
Siblings
Parents
Parity
Carcinoma
Menarche
Risk Reduction Behavior
Oral Contraceptives
Logistic Models
Odds Ratio
Confidence Intervals
Neoplasms
Datasets

Keywords

  • Case-control studies
  • Family history
  • Fertility
  • Jewish people
  • Ovarian neoplasms
  • Parity
  • Paternal age effects
  • Siblings

ASJC Scopus subject areas

  • Epidemiology

Cite this

Harlap, S., Olson, S. H., Curtin, J. P., Caputo, T. A., Nakraseive, C., Sanchez, D., & Xue, X. N. (2002). Epithelial ovarian carcinoma and fertility of parents. Epidemiology, 13(1), 59-65. https://doi.org/10.1097/00001648-200201000-00010

Epithelial ovarian carcinoma and fertility of parents. / Harlap, Susan; Olson, Sara H.; Curtin, John P.; Caputo, Thomas A.; Nakraseive, Christine; Sanchez, Damaris; Xue, Xiaonan (Nan).

In: Epidemiology, Vol. 13, No. 1, 2002, p. 59-65.

Research output: Contribution to journalArticle

Harlap, S, Olson, SH, Curtin, JP, Caputo, TA, Nakraseive, C, Sanchez, D & Xue, XN 2002, 'Epithelial ovarian carcinoma and fertility of parents', Epidemiology, vol. 13, no. 1, pp. 59-65. https://doi.org/10.1097/00001648-200201000-00010
Harlap S, Olson SH, Curtin JP, Caputo TA, Nakraseive C, Sanchez D et al. Epithelial ovarian carcinoma and fertility of parents. Epidemiology. 2002;13(1):59-65. https://doi.org/10.1097/00001648-200201000-00010
Harlap, Susan ; Olson, Sara H. ; Curtin, John P. ; Caputo, Thomas A. ; Nakraseive, Christine ; Sanchez, Damaris ; Xue, Xiaonan (Nan). / Epithelial ovarian carcinoma and fertility of parents. In: Epidemiology. 2002 ; Vol. 13, No. 1. pp. 59-65.
@article{f9fd92142ddb4b87a2df36b0463c7737,
title = "Epithelial ovarian carcinoma and fertility of parents",
abstract = "We studied the fertility of the parents of 163 women with epithelial ovarian carcinoma in two hospitals in New York City, compared with the parents of 159 controls from similar neighborhoods. We used unconditional logistic regression to control for covariates, including parity, oral contraceptive use, age at menarche, and Jewish ancestry. Compared with women with zero or one sibling, those with two, three or four or more siblings had adjusted odds ratios (95{\%} confidence intervals) of 0.91 (0.47-1.77), 0.61 (0.28-1.37), and 0.50 (0.26-0.98). On average, each additional sibling was associated with a risk reduction to 0.80 (0.66-0.98). These findings support the hypothesis that heritable conditions associated with reduced fertility of the subjects' parents may contribute to risk and may explain some of the effects of parity on the risk of this carcinoma. Alternatively, they may reflect some unidentified aspect of the environment experienced by girls growing up in small families. If confirmed in other data sets, these findings imply that sibship size might have confounded previous estimates of risk associated with a family history of cancer or with Jewish ethnicity.",
keywords = "Case-control studies, Family history, Fertility, Jewish people, Ovarian neoplasms, Parity, Paternal age effects, Siblings",
author = "Susan Harlap and Olson, {Sara H.} and Curtin, {John P.} and Caputo, {Thomas A.} and Christine Nakraseive and Damaris Sanchez and Xue, {Xiaonan (Nan)}",
year = "2002",
doi = "10.1097/00001648-200201000-00010",
language = "English (US)",
volume = "13",
pages = "59--65",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Epithelial ovarian carcinoma and fertility of parents

AU - Harlap, Susan

AU - Olson, Sara H.

AU - Curtin, John P.

AU - Caputo, Thomas A.

AU - Nakraseive, Christine

AU - Sanchez, Damaris

AU - Xue, Xiaonan (Nan)

PY - 2002

Y1 - 2002

N2 - We studied the fertility of the parents of 163 women with epithelial ovarian carcinoma in two hospitals in New York City, compared with the parents of 159 controls from similar neighborhoods. We used unconditional logistic regression to control for covariates, including parity, oral contraceptive use, age at menarche, and Jewish ancestry. Compared with women with zero or one sibling, those with two, three or four or more siblings had adjusted odds ratios (95% confidence intervals) of 0.91 (0.47-1.77), 0.61 (0.28-1.37), and 0.50 (0.26-0.98). On average, each additional sibling was associated with a risk reduction to 0.80 (0.66-0.98). These findings support the hypothesis that heritable conditions associated with reduced fertility of the subjects' parents may contribute to risk and may explain some of the effects of parity on the risk of this carcinoma. Alternatively, they may reflect some unidentified aspect of the environment experienced by girls growing up in small families. If confirmed in other data sets, these findings imply that sibship size might have confounded previous estimates of risk associated with a family history of cancer or with Jewish ethnicity.

AB - We studied the fertility of the parents of 163 women with epithelial ovarian carcinoma in two hospitals in New York City, compared with the parents of 159 controls from similar neighborhoods. We used unconditional logistic regression to control for covariates, including parity, oral contraceptive use, age at menarche, and Jewish ancestry. Compared with women with zero or one sibling, those with two, three or four or more siblings had adjusted odds ratios (95% confidence intervals) of 0.91 (0.47-1.77), 0.61 (0.28-1.37), and 0.50 (0.26-0.98). On average, each additional sibling was associated with a risk reduction to 0.80 (0.66-0.98). These findings support the hypothesis that heritable conditions associated with reduced fertility of the subjects' parents may contribute to risk and may explain some of the effects of parity on the risk of this carcinoma. Alternatively, they may reflect some unidentified aspect of the environment experienced by girls growing up in small families. If confirmed in other data sets, these findings imply that sibship size might have confounded previous estimates of risk associated with a family history of cancer or with Jewish ethnicity.

KW - Case-control studies

KW - Family history

KW - Fertility

KW - Jewish people

KW - Ovarian neoplasms

KW - Parity

KW - Paternal age effects

KW - Siblings

UR - http://www.scopus.com/inward/record.url?scp=0036136049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036136049&partnerID=8YFLogxK

U2 - 10.1097/00001648-200201000-00010

DO - 10.1097/00001648-200201000-00010

M3 - Article

C2 - 11805587

AN - SCOPUS:0036136049

VL - 13

SP - 59

EP - 65

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 1

ER -