Episodic angioedema with eosinophilia: A case associated with T cell activation and cytokine production

C. Putterman, V. Barak, Y. Caraco, T. Neuman, M. Shalit

Research output: Contribution to journalArticle

27 Scopus citations


Episodic angioedema with eosinophilia is a rare syndrome, characterized by periodic attacks of fever, myalgia, angioedema, and oliguria, associated with an increased eosinophil count. The pathogenesis of this disorder is incompletely understood. We describe an additional patient with episodic angioedema and eosinophilia, and review the literature regarding the clinical features and treatment of this disease. Previous hypotheses regarding disease mechanisms are discussed. In our patient, we found high basal levels of interleukin-1 (IL-1) and soluble interleukin-2 receptor (sIL-2R), with further increases in levels of both mediators during attacks. We suggest that IL-1 and T cell activation may play a role in the pathophysiology of episodic angioedema with eosinophilia.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalAnnals of Allergy
Issue number3
StatePublished - Jan 1 1993
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy

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