Episodic angioedema with eosinophilia

A case associated with T cell activation and cytokine production

Chaim Putterman, V. Barak, Y. Caraco, T. Neuman, M. Shalit

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Episodic angioedema with eosinophilia is a rare syndrome, characterized by periodic attacks of fever, myalgia, angioedema, and oliguria, associated with an increased eosinophil count. The pathogenesis of this disorder is incompletely understood. We describe an additional patient with episodic angioedema and eosinophilia, and review the literature regarding the clinical features and treatment of this disease. Previous hypotheses regarding disease mechanisms are discussed. In our patient, we found high basal levels of interleukin-1 (IL-1) and soluble interleukin-2 receptor (sIL-2R), with further increases in levels of both mediators during attacks. We suggest that IL-1 and T cell activation may play a role in the pathophysiology of episodic angioedema with eosinophilia.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalAnnals of Allergy
Volume70
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Angioedema
Eosinophilia
Cytokines
T-Lymphocytes
Interleukin-1
Oliguria
Interleukin-2 Receptors
Myalgia
Eosinophils
Fever
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Episodic angioedema with eosinophilia : A case associated with T cell activation and cytokine production. / Putterman, Chaim; Barak, V.; Caraco, Y.; Neuman, T.; Shalit, M.

In: Annals of Allergy, Vol. 70, No. 3, 1993, p. 243-248.

Research output: Contribution to journalArticle

Putterman, Chaim ; Barak, V. ; Caraco, Y. ; Neuman, T. ; Shalit, M. / Episodic angioedema with eosinophilia : A case associated with T cell activation and cytokine production. In: Annals of Allergy. 1993 ; Vol. 70, No. 3. pp. 243-248.
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