Epilepsy; Experimental Models

Experimental models of epilepsy have been instrumental in developing our current understanding of mechanisms and treatments for the various epilepsy syndromes. We currently have in our armamentarium in vitro and in vivo models of epileptogenesis and epilepsy, generated in a wide range of species and strains, although rodents are the most commonly used. Progress has also been made in generating computational models of epilepsy. The available models address the needs of focal or generalized types of epilepsies, and whether these are due to acquired or genetic etiologies, and they have been used to model the epilepsy syndromes across ages.