Epilepsy; Experimental Models

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Experimental models of epilepsy have been instrumental in developing our current understanding of mechanisms and treatments for the various epilepsy syndromes. We currently have in our armamentarium in vitro and in vivo models of epileptogenesis and epilepsy, generated in a wide range of species and strains, although rodents are the most commonly used. Progress has also been made in generating computational models of epilepsy. The available models address the needs of focal or generalized types of epilepsies, and whether these are due to acquired or genetic etiologies, and they have been used to model the epilepsy syndromes across ages.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages112-117
Number of pages6
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Keywords

  • Absence
  • Chemoconvulsant
  • Electrical stimulation
  • Epilepsy
  • Focal epilepsy
  • Generalized epilepsy
  • Genetic
  • Infantile spasms
  • Seizure
  • Temporal lobe epilepsy
  • Trauma

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Galanopoulou, A. S., & Moshe, S. L. (2014). Epilepsy; Experimental Models. In Encyclopedia of the Neurological Sciences (pp. 112-117). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-385157-4.00285-2