Epilepsy; Experimental Models

Aristea S. Galanopoulou; Solomon L. Moshe

doi:10.1016/B978-0-12-385157-4.00285-2

Epilepsy; Experimental Models

Aristea S. Galanopoulou, Solomon L. Moshe

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Experimental models of epilepsy have been instrumental in developing our current understanding of mechanisms and treatments for the various epilepsy syndromes. We currently have in our armamentarium in vitro and in vivo models of epileptogenesis and epilepsy, generated in a wide range of species and strains, although rodents are the most commonly used. Progress has also been made in generating computational models of epilepsy. The available models address the needs of focal or generalized types of epilepsies, and whether these are due to acquired or genetic etiologies, and they have been used to model the epilepsy syndromes across ages.

Original language	English (US)
Title of host publication	Encyclopedia of the Neurological Sciences
Publisher	Elsevier Inc.
Pages	112-117
Number of pages	6
ISBN (Electronic)	9780123851574
ISBN (Print)	9780123851581
DOIs	https://doi.org/10.1016/B978-0-12-385157-4.00285-2
State	Published - Jan 1 2014

Keywords

Absence
Chemoconvulsant
Electrical stimulation
Epilepsy
Focal epilepsy
Generalized epilepsy
Genetic
Infantile spasms
Seizure
Temporal lobe epilepsy
Trauma

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-385157-4.00285-2

Cite this

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abstract = "Experimental models of epilepsy have been instrumental in developing our current understanding of mechanisms and treatments for the various epilepsy syndromes. We currently have in our armamentarium in vitro and in vivo models of epileptogenesis and epilepsy, generated in a wide range of species and strains, although rodents are the most commonly used. Progress has also been made in generating computational models of epilepsy. The available models address the needs of focal or generalized types of epilepsies, and whether these are due to acquired or genetic etiologies, and they have been used to model the epilepsy syndromes across ages.",

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KW - Chemoconvulsant

KW - Electrical stimulation

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KW - Generalized epilepsy

KW - Genetic

KW - Infantile spasms

KW - Seizure

KW - Temporal lobe epilepsy

KW - Trauma

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BT - Encyclopedia of the Neurological Sciences

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ER -

Epilepsy; Experimental Models

Abstract

Keywords

ASJC Scopus subject areas

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