Epilepsy biomarkers

Jerome Engel, Asla Pitkanen, Jeffrey A. Loeb, F. Edward Dudek, Edward H. Bertram, Andrew J. Cole, Solomon L. Moshé, Samuel Wiebe, Frances E. Jensen, Istvan Mody, Astrid Nehlig, Annamaria Vezzani

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

A biomarker is defined as an objectively measured characteristic of a normal or pathologic biologic process. Identification and proper validation of biomarkers of epileptogenesis (the development of epilepsy) and ictogenesis (the propensity to generate spontaneous seizures) might predict the development of an epilepsy condition; identify the presence and severity of tissue capable of generating spontaneous seizures; measure progression after the condition is established; and determine pharmacoresistance. Such biomarkers could be used to create animal models for more cost-effective screening of potential antiepileptogenic and antiseizure drugs and devices, and to reduce the cost of clinical trials by enriching the trial population, and acting as surrogate markers to shorten trial duration. The objectives of the biomarker subgroup for the London Workshop were to define approaches for identifying possible biomarkers for these purposes. Research to identify reliable biomarkers may also reveal underlying mechanisms that could serve as therapeutic targets for the development of new antiepileptogenic and antiseizure compounds. Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalEpilepsia
Volume54
Issue numberSUPPL.4
DOIs
StatePublished - Aug 1 2013

Keywords

  • Biomarkers
  • Epileptogenesis
  • Ictogenesis
  • Surrogate markers
  • Therapeutic intervention

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Engel, J., Pitkanen, A., Loeb, J. A., Dudek, F. E., Bertram, E. H., Cole, A. J., Moshé, S. L., Wiebe, S., Jensen, F. E., Mody, I., Nehlig, A., & Vezzani, A. (2013). Epilepsy biomarkers. Epilepsia, 54(SUPPL.4), 61-69. https://doi.org/10.1111/epi.12299