Epigenomics

Beyond CpG islands

Melissa J. Fazzari, John M. Greally

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

Epigenomic studies aim to define the location and nature of the genomic sequences that are epigenetically modified. Much progress has been made towards whole-genome epigenetic profiling using molecular techniques, but the analysis of such large and complex data sets is far from trivial given the correlated nature of sequence and functional characteristics within the genome. We describe the statistical solutions that help to overcome the problems with data-set complexity, in anticipation of the imminent wealth of data that will be generated by new genome-wide epigenetic profiling and DNA sequence analysis techniques. So far, epigenomic studies have succeeded in identifying CpG islands, but recent evidence points towards a role for transposable elements in epigenetic regulation, causing the fields of study of epigenetics and transposable element biology to converge.

Original languageEnglish (US)
Pages (from-to)446-455
Number of pages10
JournalNature Reviews Genetics
Volume5
Issue number6
DOIs
StatePublished - Jun 2004

Fingerprint

CpG Islands
Epigenomics
epigenetics
DNA Transposable Elements
Genome
transposons
genome
DNA Sequence Analysis
functional properties
sequence analysis
genomics
nucleotide sequences
Biological Sciences
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Epigenomics : Beyond CpG islands. / Fazzari, Melissa J.; Greally, John M.

In: Nature Reviews Genetics, Vol. 5, No. 6, 06.2004, p. 446-455.

Research output: Contribution to journalArticle

Fazzari, Melissa J. ; Greally, John M. / Epigenomics : Beyond CpG islands. In: Nature Reviews Genetics. 2004 ; Vol. 5, No. 6. pp. 446-455.
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