Epigenetics, nervous system tumors, and cancer stem cells

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Recent advances have begun to elucidate how epigenetic regulatory mechanisms are responsible for establishing and maintaining cell identity during development and adult life and how the disruption of these processes is, not surprisingly, one of the hallmarks of cancer. In this review, we describe the major epigenetic mechanisms (i.e., DNA methylation, histone and chromatin modification, non-coding RNA deployment, RNA editing, and nuclear reorganization) and discuss the broad spectrum of epigenetic alterations that have been uncovered in pediatric and adult nervous system tumors. We also highlight emerging evidence that suggests epigenetic deregulation is a characteristic feature of so-called cancer stem cells (CSCs), which are thought to be present in a range of nervous system tumors and responsible for tumor maintenance, progression, treatment resistance, and recurrence. We believe that better understanding how epigenetic mechanisms operate in neural cells and identifying the etiologies and consequences of epigenetic deregulation in tumor cells and CSCs, in particular, are likely to promote the development of enhanced molecular diagnostics and more targeted and effective therapeutic agents for treating recalcitrant nervous system tumors.

Original languageEnglish (US)
Pages (from-to)3525-3556
Number of pages32
JournalCancers
Volume3
Issue number3
DOIs
StatePublished - Sep 2011

Keywords

  • Cancer
  • Cancer stem cell
  • Chromatin
  • Corest
  • Epigenetic
  • Glioblastoma multiforme
  • Nervous system tumor
  • Non-coding RNA
  • REST

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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