Epigenetics and the nervous system

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

We are in the midst of a revolution in the genomic sciences that will forever change the way we view biology and medicine, particularly with respect to brain form, function, development, evolution, plasticity, neurological disease pathogenesis and neural regenerative potential. The application of epigenetic principles has already begun to identify and characterize previously unrecognized molecular signatures of disease latency, onset and progression, mechanisms underlying disease pathogenesis, and responses to new and evolving therapeutic modalities. Moreover, epigenomic medicine promises to usher in a new era of neurological therapeutics designed to promote disease prevention and recovery of seemingly lost neurological function via reprogramming of stem cells, redirecting cell fate decisions and dynamically modulating neural network plasticity and connectivity.

Original languageEnglish (US)
Pages (from-to)602-617
Number of pages16
JournalAnnals of Neurology
Volume64
Issue number6
DOIs
StatePublished - Dec 2008

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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