Epigenetic regulatory mechanisms in vertebrate eye development and disease

Ales Cvekl, K. P. Mitton

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Eukaryotic DNA is organized as a nucleoprotein polymer termed chromatin with nucleosomes serving as its repetitive architectural units. Cellular differentiation is a dynamic process driven by activation and repression of specific sets of genes, partitioning the genome into transcriptionally active and inactive chromatin domains. Chromatin architecture at individual genes/loci may remain stable through cell divisions, from a single mother cell to its progeny during mitosis, and represents an example of epigenetic phenomena. Epigenetics refers to heritable changes caused by mechanisms distinct from the primary DNA sequence. Recent studies have shown a number of links between chromatin structure, gene expression, extracellular signaling, and cellular differentiation during eye development. This review summarizes recent advances in this field, and the relationship between sequence-specific DNA-binding transcription factors and their roles in recruitment of chromatin remodeling enzymes. In addition, lens and retinal differentiation is accompanied by specific changes in the nucleolar organization, expression of non-coding RNAs, and DNA methylation. Epigenetic regulatory mechanisms in ocular tissues represent exciting areas of research that have opened new avenues for understanding normal eye development, inherited eye diseases and eye diseases related to aging and the environment.

Original languageEnglish (US)
Pages (from-to)135-151
Number of pages17
JournalHeredity
Volume105
Issue number1
DOIs
StatePublished - Jul 2010

Fingerprint

Eye Diseases
Epigenomics
Chromatin
Vertebrates
Untranslated RNA
Nucleoproteins
Chromatin Assembly and Disassembly
Nucleosomes
DNA Methylation
Mitosis
Cell Division
Lenses
Genes
Polymers
Transcription Factors
Stem Cells
Genome
Gene Expression
DNA
Enzymes

Keywords

  • Chromatin remodeling
  • Eye development
  • Histone acetylation and methylation
  • Lens
  • Retina
  • Transcription factors

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Medicine(all)

Cite this

Epigenetic regulatory mechanisms in vertebrate eye development and disease. / Cvekl, Ales; Mitton, K. P.

In: Heredity, Vol. 105, No. 1, 07.2010, p. 135-151.

Research output: Contribution to journalArticle

Cvekl, Ales ; Mitton, K. P. / Epigenetic regulatory mechanisms in vertebrate eye development and disease. In: Heredity. 2010 ; Vol. 105, No. 1. pp. 135-151.
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