Epigenetic modifiers in normal and aberrent erythropoeisis

Sriram Sundaravel, Ulrich Steidl, Amittha Wickrema

Research output: Contribution to journalArticlepeer-review

Abstract

Erythroid differentiation program is comprised of lineage commitment, erythroid progenitor proliferation, and termination differentiation. Each stage of the differentiation program is heavily influenced by epigenetic modifiers that alter the epigenome in a dynamic fashion influenced by cytokines/humeral factors and are amicable to target by drugs. The epigenetic modifiers can be classified as DNA modifiers (DNMT, TET), mRNA modifiers (RNA methylases and demethylases) and histone protein modifiers (methyltransferases, acetyltransferases, demethylases, and deacetylases). Here we describe mechanisms by which these epigenetic modifiers influence and guide erythroid-lineage differentiation during normal and malignant erythropoiesis and also benign diseases that arise from their altered structure or function.

Original languageEnglish (US)
Pages (from-to)15-26
Number of pages12
JournalSeminars in hematology
Volume58
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Hematology

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