Epigenetic Mechanisms Underlying the Pathogenesis of Neurogenetic Diseases

Irfan A. Qureshi, Mark F. Mehler

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

There have been considerable advances in uncovering the complex genetic mechanisms that underlie nervous system disease pathogenesis, particularly with the advent of exome and whole genome sequencing techniques. The emerging field of epigenetics is also providing further insights into these mechanisms. Here, we discuss our understanding of the interplay that exists between genetic and epigenetic mechanisms in these disorders, highlighting the nascent field of epigenetic epidemiology—which focuses on analyzing relationships between the epigenome and environmental exposures, development and aging, other health-related phenotypes, and disease states—and next-generation research tools (i.e., those leveraging synthetic and chemical biology and optogenetics) for examining precisely how epigenetic modifications at specific genomic sites affect disease processes.

Original languageEnglish (US)
Pages (from-to)708-720
Number of pages13
JournalNeurotherapeutics
Volume11
Issue number4
DOIs
StatePublished - Oct 18 2014

Keywords

  • Chromatin
  • DNA methylation
  • Epigenetic
  • Epigenome
  • Histone
  • Noncoding RNA

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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